| Project/Area Number |
21592360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
KUBOTA Satoshi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90221936)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIGAWA Masaharu 岡山大学, 大学院・医歯薬学総合研究科, 教授 (20112063)
HATTORI Takako 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00228488)
NISHIDA Takashi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (30322233)
AOYAMA Eriko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10432650)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口腔生化学 / 細胞生物学 / 再生医工学 / CCN family / aptamer / CCN2 / CTGF / chondrocyte / peptide / osteoclast / CCNファミリー / アプタマー / 軟骨細胞 / ペプチド |
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| Research Abstract |
CCN2 is known to promote harmonized regeneration of bone and cartilage tissues and to be involved in fibrotic disorders of a variety of organs. Therefore, regulating CCN2 function is of great significance in the field of regenerative medicine and fibrosis therapeutics. In this study, we designed, synthesized and evaluated the effect of aptamers that bind to CCN2, in order to control the molecular action of CCN2. As a result, we could obtain a few aptamers that could promote cartilage regeneration, or might regulate bone remodeling.
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