| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Research Abstract |
To gain insight into how taste recognition is accomplished in the brain, we applied a genetic approach to delineate the neuronal circuitries of sweet and bitter taste by selectively expressing the transneuronal tracer, WGA-DsRed, in either bitter-or sweet-responsive taste receptor cells in mice, and by visualizing the spatial distribution of neurons in the brain, which were labeled by WGA-DsRed originating from each class of taste receptor cells. Locations of the WGA-DsRed-labeled neurons revealed segregation of bitter-and sweet-inputs in the gustatory cortex. Combination of genetic tracing with electrophysiological recordings and immunohistochemistry enables to functionally define the neurons that process specific taste information and that integrate taste and the other viscerosensory information.
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