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Therapeutic Establishment for Gingival Hyperplasia and Scar Formation by Use of Collagen-Digestible Proteases

Research Project

Project/Area Number 21592367
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionNagasaki University

Principal Investigator

NEMOTO Takayuki  長崎大学, 大学院・医歯薬学総合研究科, 教授 (90164665)

Co-Investigator(Kenkyū-buntansha) NEMOTO Yuko  長崎大学, 大学院・医歯薬学総合研究科, 准教授 (10164667)
BABA Tomomi  長崎大学, 大学院・医歯薬学総合研究科, 助教 (60189727)
KOBAYAKAWA Takeshi  長崎大学, 大学院・医歯薬学総合研究科, 教務職員 (10153587)
ONO Toshio  長崎大学, 大学院・医歯薬学総合研究科, 助教 (80050607)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsブドウ球菌性熱傷様皮膚症候群 / とびひ / 歯周病 / Staphylococcus aureus / Porphyromonas gingivalis / ジペプチジルペプチダーゼ / 熱傷様皮膚症候群 / 表皮剥脱毒素 / DPP7 / DPP11 / ETA / 黄色ブドウ球菌 / セリンプロテアーゼ / グルタミン酸特異的 / リコンビナント体 / コラーゲン / グルタミン酸特異的プロテアーゼ / コアグラーゼ ポジティブ / プロセシング
Research Abstract

Porphyromonas gingivalis and Porphyromonas endodontalis, asaccharolytic black-pigmented anaerobes, are predominant pathogens of human chronic and periapical periodontitis, respectively. They incorporate di-and tri-peptides from the environment as carbon and energy sources. In the present study, we cloned a novel dipeptidyl peptidase(DPP) gene of P. endodontalis ATCC 35406, designated as DPP11. A homology search revealed the presence of a P. gingivalis orthologue, PGN0607, which has been categorized as an isoform of authentic DPP7. DPP11 specifically removed dipeptides from oligopeptides with the penultimate N-terminal Asp and Glu. Arg_<670> is a unique amino acid completely conserved in all DPP11 members, whilst this residue is converted to Gly in all authentic DPP7 members. Substitution analysis suggested that Arg_<670> interacts with an acidic residue of the substrate. Considered to preferentially utilize acidic amino acids, DPP11 ensures efficient degradation of oligopeptide substrates in these gram-negative anaerobic rods.
In order to investigate the mechanism of Staphylococcal scalded skin syndrome(SSSS) caused by exfoliative toxin A(ETA), we expressed and purified ETA and its N-terminally truncated(Δ38 andΔ57) and inactive(Ser233Ala) derivatives in E. coli. Recombinant ETA(wt) showed the peptidase activity for LLE-MCA. This is the first report that ETA showed the peptidase activity other than Dsg1. ETA and its dirivatives exerted toxin activity to newborn mice, if ETA derivatives(wt andΔ38) possessed the peptidase activity, while ETAs with no peptidase activity(Δ57 and SerΔ233Ala) did not cause the disease. This finding indicated that the peptidase activity of ETA was indispensible for the toxin activity.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (56 results)

All 2012 2011 2010 2009 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (32 results) Remarks (2 results)

  • [Journal Article] Asp-and Glu-specific novel dipeptidyl peptidase 11 of Porphyromonas gingivalis that ensures utilization of proteinaceous energy sources2011

    • Author(s)
      Ohara-Nemoto Y, Shimoyama Y, Kimura Y, Kon A, Haraga H, Ono T, and Nemoto TK
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 38115-38127

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma2011

    • Author(s)
      Yamada S, Yanamoto S, Kawasaki G, Rokutanda S, Yonezawa H, Kawakita A, and Nemoto TK
    • Journal Title

      Cancer Lett

      Volume: 303 Pages: 84-91

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asp- and Glu-specific novel dipeptidyl peptidase 11 of Porphyromonas gingivalis that ensures utilization of proteinaceous energy sources2011

    • Author(s)
      Ohara-Nemoto Y, Shimoyama Y, Kimura S, Kon A, Haraga H, Nemoto TK
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 44 Pages: 38115-38127

    • DOI

      10.1074/jbc.m111.278572

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma.2011

    • Author(s)
      Shin-ichi Yamada
    • Journal Title

      Cancer Lett.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNAi-mediated down-regulation ofτ-actinin-4 decreases invasion potential in oral 4 squamous cell carcinoma2010

    • Author(s)
      Yamada S, Yanamoto S, Yoshida H, Yoshitomi I, Kawasaki G, Mizuno A and Nemoto TK
    • Journal Title

      Int. J. Oral. Maxillofac. Surg

      Volume: 39(1) Pages: 61-67

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of cortactin increases invasion potential in oral squamous cell carcinoma2010

    • Author(s)
      Yamada S, Yanamoto S, Kawasaki G, Mizuno A and Nemoto TK
    • Journal Title

      Pathol. Oncol. Res

      Volume: 16(4) Pages: 523-531

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases2010

    • Author(s)
      Ono T, Ohara-Nemoto Y, Shimoyama Y, Okawara H, Kobayakawa T, Baba TT, Kimura S, and Nemoto TK
    • Journal Title

      Biol. Chem

      Volume: 391 Pages: 1221-1232

    • NAID

      120006984895

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases.2010

    • Author(s)
      Ono Toshio
    • Journal Title

      Biol.Chem.

      Volume: 391 Pages: 1221-1262

    • NAID

      120006984895

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of cortactin increases invasion potential in oral squamous cell carcinoma.2010

    • Author(s)
      Shin-ichi Yamada
    • Journal Title

      Pathol.Oncol.Res.

      Volume: 39 Pages: 523-531

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNAi-mediated down-regulation of a-actinin-4 decreases invasion potential in oral squamous cell carcinoma.2010

    • Author(s)
      Shin-ichi Yamada
    • Journal Title

      Int.J.Oral.Maxillofac.Surg.

      Volume: 39 Pages: 61-67

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between oral status and prevalence of periodontopathic bacteria on tongue of 85-years elderly.2010

    • Author(s)
      Kishi Mitsuo
    • Journal Title

      J.Med.Microbiol.

      Volume: 59 Pages: 1354-1359

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel aspartate-specific dipeptidylpeptidase produced from Porphyromonas endodontalis.2010

    • Author(s)
      Kimura Sigenobu
    • Journal Title

      Interface Oral Health Science

      Volume: 2009 Pages: 265-266

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNAi-mediated down-regulation of α-actinin-4 decreases invasion potential in oral squamous cell carcinoma.2010

    • Author(s)
      Yamada, S., Yanamoto, S., Yoshida, H., Yoshitomi, I., Kawasaki, G., Mizuno A., Nemoto, T.K.
    • Journal Title

      Int J Oral Maxillofac Surg. 39(1)

      Pages: 61-67

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of cortactin increases invasion potential in oral squamous cell carcinoma.2010

    • Author(s)
      Yamada S, Yanamoto S, Kawasaki G, Mizuno A, Nemoto TK.
    • Journal Title

      Pathol Oncol Res. (in press.)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship of the salivary quantitative levels of Streptococcus mutans and S. sobrinus in mothers to the caries status and the colonization in plaque of mutans streptococci in their 2. 5-year-old children.2009

    • Author(s)
      Kishi M, Abe A, Kishi K, Ohara-Nemoto, Y, Kimura S, Yonemitsu M
    • Journal Title

      Comm Dent Oral Epidemiol

      Volume: 37(3) Pages: 241-249

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influences of fosfomycin on Shiga toxin gene expression from Shiga toxin-producing Escherichia coli2009

    • Author(s)
      Ichinohe N, Ohara-Nemoto Y, Nemoto TK, Kimura S, Ichinohe S
    • Journal Title

      J Med Microbiol

      Volume: 58(7) Pages: 971-973

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single nucleotide polymorphism that accompanies a missense mutation(Gln488His) impedes the dimerization of Hsp902009

    • Author(s)
      Kobayakawa T, Yamada S, Mizuno A, Ohara-Nemoto Y, Nemoto TK
    • Journal Title

      Protein J

      Volume: 28(1) Pages: 24-28

    • NAID

      120006983318

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of three amino acids that caused the alteration of proteolytic activities of staphylococcal glutamyl endopeptidases2009

    • Author(s)
      Nemoto TK, Ono T, Shimoyama Y, Kimura S, Ohara-Nemoto Y
    • Journal Title

      Biol Chem

      Volume: 390(3) Pages: 277-285

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 幼若マウスにおける実験的水疱性膿痂疹作成と表皮剥奪毒素による角化細胞障害の顕微鏡的観察2009

    • Author(s)
      永海多恵, 根本優子, 広田剛, 石崎美智子, 多田讓治
    • Journal Title

      化学療法の領域

      Volume: 25(8) Pages: 109-116

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of three amino acids that caused the alteration of proteolytic activities of staphylococcal glutamyl endopeptidases.2009

    • Author(s)
      Nemoto TK, Ono T, Shimoyama Y, Kimura S, Ohara-Nemoto Y
    • Journal Title

      Biol.Chem. 390

      Pages: 277-285

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single nucleotide polymorphism that accompanies a missense mutation(Gln488His)impedes the dimerization of Hsp90.2009

    • Author(s)
      Kobayakawa T, Yamada S, Mizuno A, Ohara-Nemoto Y, Baba TT, Nemoto TK
    • Journal Title

      Protein J. 28

      Pages: 24-28

    • NAID

      120006983318

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of fosfomycin on Shiga toxin-producing Escherichia coli : quantification of copy numbers of Shiga toxin genes and their expression levels using real-time PCR.2009

    • Author(s)
      Ichinohe N, Ohara-Nemoto Y, Nemoto TK, Kimura S, Ichinohe S.
    • Journal Title

      J.Med.Microbiol. 58

      Pages: 971-973

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 表皮剥脱毒素ETAの生物活性とプロテアーゼ活性の関係2012

    • Author(s)
      達聖月, 小早川健, 根本孝幸, 馬場友巳, 根本優子
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Porphyromonas属新規Asp/ Glu特異的ジペプチジルペプチダーゼの同定2012

    • Author(s)
      根本孝幸, シャークラオフ, 小野俊雄, 下山佑, 木村重信, 根本優子
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] DPP 7と新規Asp/ Glu特異的DPP11を含むS46ペプチダーゼファミリーの再分類2012

    • Author(s)
      シャークラオフ, 根本優子, 小野俊雄, 星野倫範, 藤原卓, 根本孝幸
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 表皮剥脱毒素ETA N末端領域の生物活性に及ぼす作用2011

    • Author(s)
      達聖月, 根本優子, 馬場友巳, 小早川健, 藤田修一, 池田通, 大井久美子, 根本孝幸
    • Organizer
      第53回歯科基礎医学学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨芽細胞に発現するアクアポリン2011

    • Author(s)
      馬場友巳, 宮崎敏博, 達聖月, 根本優子, 根本孝幸
    • Organizer
      第53回歯科基礎医学学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Porphyromonas属菌が産生するAsp/ Glu特異的新規ジペプチジルペプチダーゼ(DPP) 112011

    • Author(s)
      根本優子, 下山佑, 木村重信, 根本孝幸
    • Organizer
      第53回歯科基礎医学学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Porphyromonas gingivalis DPP11の酵素活性とAsp/ Glu特異性を規定するArg^<670>2011

    • Author(s)
      根本孝幸, 小野俊雄, 下山佑, 木村重信, 根本優子
    • Organizer
      第53回歯科基礎医学学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Porphyromonas属菌が産生するAsp/Glu特異的新規ジペプチジルペプチダーゼ(DPP)112011

    • Author(s)
      根本優子, 下山佑, 木村重信, 根本孝幸
    • Organizer
      第53回歯科基礎医学学術大会
    • Place of Presentation
      長良川国際会議場岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 表皮剥脱毒素ETA N末端領域の生物活性に及ぼす作用2011

    • Author(s)
      達聖月, 根本優子, 馬場友巳, 小早川健, 藤田修一, 池田通, 大井久美子, 根本孝幸
    • Organizer
      第53回歯科基礎医学学術大会
    • Place of Presentation
      長良川国際会議場岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨芽細胞に発現するアクアポリン2011

    • Author(s)
      馬場友巳, 宮崎敏博, 達聖月, 根本優子, 根本孝幸
    • Organizer
      第53回歯科基礎医学学術大会
    • Place of Presentation
      長良川国際会議場岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Porphyromonas gingivalis DPP11の酵素活性とAsp/Glu特異性を規定するArg6702011

    • Author(s)
      根本孝幸, 小野俊雄, 下山佑, 木村重信, 根本優子
    • Organizer
      第53回歯科基礎医学学術大会
    • Place of Presentation
      長良川国際会議場岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Biochemical characterization of DPP11 : Importance of arginine^<670> for the enzymatic activity specific for the P1-position acidic residue.2011

    • Author(s)
      Nemoto TK, Ono T, Rouf SMA, Shimoyama Y, Kimura S, Tetsuo F, and Ohara-Nemoto Y
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Biochemical characterization of DPP11 : Importance of arginine670 for the enzymatic activity specific for the P1-position acidic residue2011

    • Author(s)
      Nemoto TK, Ono T, Rouf SMA, Shimoyama Y, Kimura S, Tetsuo F, Ohara-Nemoto Y
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] A novel Asp and Glu specific dipeptidyl peptidase from Porphyromonas endodontalis. 38th Asia Pacific Dental Students Association Congress2011

    • Author(s)
      Tetsuo F, Ohara-Nemoto Y, Shimoyama Y, Kimura S, and Nemoto TK
    • Organizer
      Scientific Research Competition, Babcock
    • Place of Presentation
      Thailand
    • Year and Date
      2011-08-17
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel Asp and Glu specific dipeptidyl peptidase from Porphyromnas endodontalis2011

    • Author(s)
      Tetsuo F, Ohara-Nemoto Y, Shimoyama Y, Kimura S, Nemoto TK
    • Organizer
      38th Asia Pacific Dental Students Association Congress, Scientific Research Competition
    • Place of Presentation
      バンコクタイ
    • Year and Date
      2011-08-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Autocatalytic propeptide processing facilitates the final hetero-catalytic maturation of glutamyl endopeptidase GluV82011

    • Author(s)
      Ohara-Nemoto Y, Rouf SMA, Shimoyama Y, Kimura S, Ono T, and Nemoto TK
    • Organizer
      111th General Meeting of American Society for Microbiology
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2011-05-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Auto-catalytic propeptide processing facilitates the final hetero-catalytic maturation of glutamyl endopeptidase GluV82011

    • Author(s)
      Ohara-Nemoto Y, Rouf SMA, Shimoyama Y, Kimura S, Ono T, Nemoto TK
    • Organizer
      111th General Meeting of American Society for Microbiology
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Rapid identification of Abiotrophia/ Granulicatella species using by 16S rRNA based PCR and RFLP2011

    • Author(s)
      Shimoyama Y, Sasaki M, Ohara-Nemoto Y, and Nemoto TK, Ishikawa T, Kimura S
    • Organizer
      4th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Auto-catalytic processing of prosequence prior to maturation of Staphylococcal glutamyl endopeptidases.2010

    • Author(s)
      Shakh M.A.Rouf
    • Organizer
      第33回日本分子生物学会年会,第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規V8プロテアーゼファミリー遺伝子のクローニングとV8プロテアーゼ活性に重要なN末バリンと185-195領域の同定2010

    • Author(s)
      根本孝幸
    • Organizer
      第52回歯科基礎医学学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural chemistry of Staphylococcal aureus glutamyl endopeptidases.2010

    • Author(s)
      Yuko Ohara-Nemoto
    • Organizer
      88th General Session of International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural chemistry of Staphylococcal aureus glutamyl endopeptidases2010

    • Author(s)
      Ohara-Nemoto Y, Rouf SMA, Shimoyama Y, Kimura S, Nemoto TK
    • Organizer
      88th General Session of International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] SLPI production from gingival epithelial cells against Porphyromonas gingivalis infection2010

    • Author(s)
      Ishikawa T, Ohara-Nemoto Y, Shimoyama Y, Sasaki M, Kimura S
    • Organizer
      88th General Session of International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] Prediction of colonization of periodontopathogens in plaque by VSC measurement2010

    • Author(s)
      Kishi M, Ohara-Nemoto Y, Kimura S, Aizawa F, Kishi K, Takahashi M, Yonemitsu M
    • Organizer
      88th General Session of International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規V8プロテアーゼファミリー遺伝子のクローニングと8プロテアーゼ活性に重要なN末バリンと185-195領域の同定2010

    • Author(s)
      根本孝幸, 小野俊雄, 下山佑, 木村重信, 大河原久実, 根本優子
    • Organizer
      第52回歯科基礎医学学術大会
    • Place of Presentation
      松戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Autocatalytic processing of prosequence prior to maturation of Staphylococcal glutamyl endopeptidases2010

    • Author(s)
      Shakh M. A. Rouf, 根本優子, 小野俊雄, 下山佑, 木村重信, 根本孝幸
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Staphylococcus属Glu-プロテアーゼの発現と酵素活性を決定する3アミノ酸の同定.2009

    • Author(s)
      根本孝幸, 小野俊雄, 根本優子
    • Organizer
      第51回歯科基礎医学学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Staphylococcus属Glu-プロテアーゼの発現と酵素活性を決定する3アミノ酸の同定2009

    • Author(s)
      根本孝幸, 小野俊雄, 根本優子
    • Organizer
      第51回歯科基礎医学学術大会
    • Place of Presentation
      第51回歯科基礎医学学術大会
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Three amino acid residues define the proteolytic activities of Staphylococcal Glu-specific proteases2009

    • Author(s)
      Ohara-Nemoto Y, Ono T, Shimoyama Y, 6 Kimura S, Nemoto TK
    • Organizer
      109th General Meeting of American Society for Microbiology
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] The production of secretory leukocyte protease inhibitor(SLPI) from gingival epithelial cells in response to Porphyromonas gingivalis lipopolysaccharides2009

    • Author(s)
      Ishikawa T, Ohara-Nemoto Y, Tajika S, Sasaki M, Kimura S
    • Organizer
      3rd International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel aspartate-specific dipeptidylpeptidase produced from Porphyromonas endodontalis2009

    • Author(s)
      Haraga H, Ohara-Nemoto Y, Nemoto TK, Shimoyama Y, Sasaki M, Kimura S
    • Organizer
      3rd International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Ultrastructural analysis of osteoblasts, osteocytes and odontoblasts in Runx2 transgenic mice2009

    • Author(s)
      Miyazaki T, Moriishi T, Izumi S, Baba TT, and Komori T
    • Organizer
      The 6th International Symposium on Electron Microscopy in Medicine and Biology(6th ISEM09)
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://naosite.ib.nagasaki-u.ac.jp/dspace/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://naosite.ib.nagasaki-u.ac.jp/dspace/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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