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A study on the mechanism of bone resorption by gingipains, the major proteases produced by Porphyromonas gingivalis

Research Project

Project/Area Number 21592372
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionShowa University

Principal Investigator

MIYAMOTO Yoichi  昭和大学, 歯学部, 准教授 (20295132)

Co-Investigator(Kenkyū-buntansha) TAKAMI Masamichi  昭和大学, 歯学部, 講師 (80307058)
Co-Investigator(Renkei-kenkyūsha) IMAMURA Takahisa  熊本大学, 大学院・生命科学研究部, 准教授 (20176499)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords歯周病 / ジンジパイン / 破骨細胞 / 分化 / 細胞分化
Research Abstract

Porphyromonas gingivalis is one of the major pathogens of periodontitis, a condition characterized by excessive alveolar bone resorption by osteoclasts. The bacterium produces cysteine proteases called gingipains, which are classified according to their cleavage-site specificity into lysine-specific(Kgp) and arginine-specific gingipains(Rgps). In this study, we examined the effects of gingipains on osteoclast differentiation. In co-cultures of mouse bone marrow cells and osteoblasts, formation of multinucleated osteoclasts induced by 1α, 25-dihydroxyvitamin D_3[1α, 25(OH)_2D_3] was augmented by Kgp but not by RgpB. A physiological concentration(0.1 nM) of 1α, 25(OH)_2D_3 induced the osteoclast formation in the presence of 100 nM Kgp to the extent comparable to that induced by 10 nM 1α, 25(OH)_2D_3. Kgp also enhanced osteoclastogenesis induced by various microbial components including lipopolysaccharide. Combined use of Kgp and 1α, 25(OH)_2D_3 or lipopolysaccharide also increased the number of resorption pits developed on dentin slices, indicating the osteoclasts formed in the presence of Kgp possess bone-resorbing activity. The enhanced osteoclastogenesis by Kgp was correlated with a depletion of osteoprotegerin in co-culture media and proteolytic activity-dependent, since benzyloxycarbonyl-phenylalanyl-lysyl-acycloxyketone, an inhibitor of Kgp, completely abolished osteoclastogenesis induced by Kgp. Kgp digested osteoprotegerin, since its recombinant protein was susceptible to degradation by Kgp in the presence of serum. As a result, Kgp did not augment osteoclastogenesis in co-cultures of osteoprotegerin-deficient osteoblasts and bone marrow cells. In addition, enhanced osteoclastogenesis by Kgp was abolished by excess amount of recombinant osteoprotegerin. These findings suggest that degradation of osteoprotegerin is one of the mechanisms underlying promotion of osteoclastogenesis by Kgp.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (66 results)

All 2011 2010 2009 Other

All Journal Article (21 results) (of which Peer Reviewed: 9 results) Presentation (41 results) Remarks (4 results)

  • [Journal Article] Expression of POEM, s positive regulator of osteoblast differentiation, is suppressed by TNF-α2011

    • Author(s)
      Tsukasaki M, Yamada A, Suzuki D, Aizawa R, Miyazono A, Miyamoto Y, Suzawa T, Takami M, Yoshimura K, Morimura N, Yamamoto M, Kamijo R
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Pages: 766-770

    • Related Report
      2011 Final Research Report
  • [Journal Article] Identification and Isolation of Neural Crest Derived Cells in Nasal Concha2011

    • Author(s)
      Ono M, Suzawa T, Takami M, Miyauchi T, Ogasawara A, Yamada A, Hosono T, Arata S, Miyamoto Y, Baba K, Nakamura M, Osumi N, Maki K, Kamijo R
    • Journal Title

      Jpn J Tissue Cult Dent Res

      Volume: 20 Pages: 29-35

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Roles of gingipains in periodontal bone loss2011

    • Author(s)
      Yasuhara R, Miyamoto Y
    • Journal Title

      J Oral Biosci

      Volume: 53 Pages: 197-205

    • NAID

      10029494786

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1. via activation of nuclear factor-. B and expression of phagocyte-type NADPH-oxidase2011

    • Author(s)
      Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 14744-14752

    • Related Report
      2011 Final Research Report
  • [Journal Article] Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α2011

    • Author(s)
      Tsukasaki M, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Issue: 4 Pages: 766-770

    • DOI

      10.1016/j.bbrc.2011.06.048

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1β via activation of nuclear factor-κB and expression of phagocyte-type NADPH-oxidase2011

    • Author(s)
      Yoshimura K, et al
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 17 Pages: 14744-14752

    • DOI

      10.1074/jbc.m111.221259

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of bone morphogenetic protein-2-induced ectopic bone formation by transforming growth factor-β12010

    • Author(s)
      Tachi K, Takami M, Sato H, Sato H, Mochizuki A, Zhao B, Miyamoto Y, Tsukasaki H, Inoue T, Shintani S, Koike T, Honda Y, Suzuki O, Baba K, Kamijo R
    • Journal Title

      Tissue Engineering

      Volume: 17 Pages: 597-606

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Bone morphogenetic protein 2 enhances mouse osteoclast differentiation via increased levels of receptor activator of NF-κB ligand expression in osteoblasts2010

    • Author(s)
      Tachi K, Takami M, Zhao B, Mochizuki A, Yamada A, Miyamoto Y, Inoue T, Baba K, Kamijo R
    • Journal Title

      Cell Tissue Res

      Volume: 342 Pages: 213-220

    • Related Report
      2011 Final Research Report
  • [Journal Article] Caebonic anhydrase II regulates differentiation of ameloblasts via intracellular pH-dependent JNK signaling pathway2010

    • Author(s)
      Wang X, Suzawa T, Ohtsuka H, Zhao B, Miyamoto Y, Miyauchi T, Nishimura R, Inoue T, Nakamura M, Baba K, Kamijo R
    • Journal Title

      J Cell Physiol

      Volume: 225 Pages: 709-719

    • Related Report
      2011 Final Research Report
  • [Journal Article] Overview : Molecular regulation of mineralization and its failure-From disclosure of mechanisms to clinical implications2010

    • Author(s)
      Miyamoto Y, Kamijo R
    • Journal Title

      J Oral Biosci

      Volume: 52 Pages: 1-5

    • NAID

      10027105118

    • Related Report
      2011 Final Research Report
  • [Journal Article] Caebonic anhydrase II regulates differentiation of ameloblasts via intracellular pH-dependent JNK signaling pathway2010

    • Author(s)
      Wang X, et al.
    • Journal Title

      Journal of Cellular Physiology

      Volume: 225 Pages: 709-719

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone morphogenetic protein 2 enhances mouse osteoclast differentiation via increased levels of receptor activator of NF-κB ligand expression in osteoblasts2010

    • Author(s)
      Tachi K, et al.
    • Journal Title

      Cell and Tissue Research

      Volume: 342 Pages: 213-220

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overview : Molecular regulation of mineralization and its failure-From disclosure of mechanisms to clinical implications2010

    • Author(s)
      〓oichi Miyamoto, Ryutaro Kamij〓
    • Journal Title

      Journal of Oral Biosciences 52

      Pages: 1-5

    • NAID

      10027105118

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The light and dark side of bisphosphonates2009

    • Author(s)
      Jimi E, Takami M, Hiraga T, Nakamura I, Urade M, Miyamoto Y
    • Journal Title

      J Oral Biosci

      Volume: 51 Pages: 177-187

    • NAID

      10027104865

    • Related Report
      2011 Final Research Report
  • [Journal Article] Change in salivary levels of chromogranin A in children by hearing dental air turbine noise2009

    • Author(s)
      Okano A, Miyamoto Y, Asari J, Kamijo R, Inoue M
    • Journal Title

      Pediat Dent J

      Volume: 19 Pages: 220-227

    • NAID

      10027485203

    • Related Report
      2011 Final Research Report
  • [Journal Article] Osteoclast differentiation induced by synthetic octacalcium phosphate through receptor activator of NF-. B ligand expression in osteoblasts2009

    • Author(s)
      Takami M, Mochizuki A, Yamada A, Tachi K, Zhao B, Miyamoto Y, Anada T, Honda Y, Inoue T, Nakamura M, Suzuki O, Kamijo R
    • Journal Title

      Tissue Engineering

      Volume: 15 Pages: 3991-4000

    • Related Report
      2011 Final Research Report
  • [Journal Article] Lysine-specific gingipain promotes lipopolysaccharide-and active vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin2009

    • Author(s)
      Yasuhara R, Miyamoto Y, Takami M, Imamura T, Yamada A, Suzawa T, Potempa J, Yoshimura K, Kamijo R
    • Journal Title

      Biochem J

      Volume: 419 Pages: 159-166

    • Related Report
      2011 Final Research Report
  • [Journal Article] Lysine-specific gingipain promotes lipopolysaccharide- and active vitamin D_3-induced osteoclast differentiation by degrading2009

    • Author(s)
      Rika Yasuhara, et al.
    • Journal Title

      Biochemical Journal 419

      Pages: 159-166

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclast differentiation induced by synthetic octacalcium phosphate through receptor activator of NF-κB ligand expression in osteoblasts2009

    • Author(s)
      Masamichi Takami, et al.
    • Journal Title

      Tissue Engineering 15

      Pages: 3991-4000

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Change in salivary levels of chromogranin A in children by hearing dental air turbine noise2009

    • Author(s)
      Akiko Okano, et al.
    • Journal Title

      Pediatric Dental Journal 19

      Pages: 220-227

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The light and dark side of bisphosphonates2009

    • Author(s)
      Eijiro Jimi, et al.
    • Journal Title

      Journal of Oral Biosciences 51

      Pages: 177-187

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] TNF-は細胞接着分子POEMの発現を抑制し、骨芽細胞分化を制御している2011

    • Author(s)
      塚崎雅之, 他
    • Organizer
      第31回昭和歯学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-02
    • Related Report
      2011 Final Research Report
  • [Presentation] TNF-αは細胞接着分子POEMの発現を抑制し、骨芽細胞分化を制御している2011

    • Author(s)
      塚崎雅之, 他
    • Organizer
      第31回昭和歯学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 活性窒素・酸素種による軟骨細胞変性2011

    • Author(s)
      宮本洋一
    • Organizer
      埼玉医科大学ゲノム医学研究センター・セミナー
    • Place of Presentation
      埼玉
    • Year and Date
      2011-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 血管内皮細胞がラット歯髄細胞へ与える影響について2011

    • Author(s)
      増田宜子, 他
    • Organizer
      日本歯科保存学会2011年度秋季学術大会(第135回)
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Enhancement of inflammatory osteoclastogenesis by lysine-specific gingipain2011

    • Author(s)
      Akiyama T, et al.
    • Organizer
      IOF Regionals-2nd Asia-Pacific Osteoporosis and Bone Meeting and the Australian and New Zealand Bone and Mineral Society(ANZBMS) Annual Scientific Meeting with the Japanese Society for Bone and Mineral Society(JSBMR)
    • Place of Presentation
      Gold Coast, Australia
    • Related Report
      2011 Final Research Report
  • [Presentation] Double stranded RNA increases bone mass in osteoporosis model mice by inhibiting osteoclastogenesis via interferon-./STAT1 pathway2011

    • Author(s)
      Miyamoto A, et al.
    • Organizer
      IOF Regionals-2nd Asia-Pacific Osteoporosis and Bone Meeting and the Australian and New Zealand Bone and Mineral Society(ANZBMS) Annual Scientific Meeting with the Japanese Society for Bone and Mineral Society(JSBMR)
    • Place of Presentation
      Gold Coast, Australia
    • Related Report
      2011 Final Research Report
  • [Presentation] Monocarboxylate transporter-1は骨芽細胞分化を正に制御する2011

    • Author(s)
      吉村健太郎, 他
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] リシン特異的ジンジパインによる炎症性骨破壊促進機構の解析2011

    • Author(s)
      秋山智人, 他
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 二本鎖RNAアナログはインターフェロンβ/STAT1経路を介して破骨細胞分化を抑制し骨粗鬆症モデル動物の骨量を増加させる2011

    • Author(s)
      宮本阿礼, 他
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] Monocarboxylate transporter-1 is required for cell death in mouse chondrocyte-kike ATDC5 cells exposed to interleukin-1. via late phase activation of NF-. B and expression of phagocyte-type NADPH-oxidase.2011

    • Author(s)
      Yoshimura K, et al.
    • Organizer
      The Joint International Meeting Sponsored by The Japanese Society for Interferon and Cytokine Research
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Dual effects of lysine-specific gingipain on inflammatory osteoclastogenesis2011

    • Author(s)
      Akiyama T, et al.
    • Organizer
      The Joint International Meeting Sponsored by The Japanese Society for Interferon and Cytokine Research, The Japanese Society for Macrophage Molecular and Cell Biology, Cytokine/Chemokine, Immunity, and Diseases
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Monocarboxylate transporter-1 is involved in the activation of NF-κB and expression of phagocyte-type NADPH-oxidase in mouse chondrocytes exposed to interleukin-1β2011

    • Author(s)
      Yoshimura K, et al.
    • Organizer
      31st Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Denver, Colorado, U. S. A
    • Related Report
      2011 Final Research Report
  • [Presentation] Dual effects of lysine-specific gingipain on inflammatory osteoclastogenesis2011

    • Author(s)
      Akiyama T, et al
    • Organizer
      The Joint International Meeting Sponsored by The Japanese Society for Interferon and Cytokine Research, The Japanese Society for Macrophage Molecalar and Cell Biology, Cytokine/Chemokine, Immunity, and Diseases
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] Monocarboxylate transporter-1 is required for cell death in mouse chondrocyte-kike ATDC5 cells exposed to interleukin-1β via late phase activation of NF-κB and expression of phagocyte-type NADPH-oxidase2011

    • Author(s)
      Yoshimura K, et al
    • Organizer
      The Joint International Meeting Sponsored by The Japanese Society for Interferon and Cytokine Research, The Japanese Society for Macrophage Molecular and Cell Biology, Cytokine/Chemokine, Immunity, and Diseases
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] 二本鎖RNAアナログはインターフェロンβ/STAT1経路を介して破骨細胞分化を抑制し骨粗鬆症モデル動物の骨量を増加させる2011

    • Author(s)
      宮本阿礼, 他
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] Double stranded RNA increases bone mass in osteoporosis model mice by inhibiting osteoclastogenesis via interferon-β/STAT1 pathway2011

    • Author(s)
      Miyamoto A, et al
    • Organizer
      IOF Regionals-2nd Asia-Pacific Osteoporosis and Bone Meeting and the Australian and New Zealand Bone and Mineral Society (ANZBMS) Annual Scientific Meeting with the Japanese Society for Bone and Mineral Society (JSBMR)
    • Place of Presentation
      Gold Coast, Australia
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enhancement of inflammatory osteoclastogenesis by lysine-specific gingipain2011

    • Author(s)
      Akiyama T, et al
    • Organizer
      IOF Regionals-2nd Asia-Pacific Osteoporosis and Bone Meeting and the Australian and New Zealand Bone and Mineral Society (ANZBMS) Annual Scientific Meeting with the Japanese Society for Bone and Mineral Society (JSBMR)
    • Place of Presentation
      Gold Coast, Australia
    • Related Report
      2011 Annual Research Report
  • [Presentation] Carbonic anhydrase IX suppresses hypertrophic differentiation of chondrocytes2010

    • Author(s)
      Maruyama T, et al.
    • Organizer
      The 32nd Annual Meeting of American Society of Bone and Mineral Research
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Monocarboxylate transporter-1は、IL-1β刺激後の軟骨細胞で後期NF-κB活性化を起こし、NOX-2発現とそれに依存した細胞死を誘導する2010

    • Author(s)
      吉村健太郎, 他
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Monocarboxylate transporter-1は、IL-1β刺激後の軟骨細胞で後期NF-κB活性化を起こし、NOX-2発現とそれに依存した細胞死を誘導する2010

    • Author(s)
      吉村健太郎, 他
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Monocarboxylate transporter-1 is involved in activation of nuclear factor-κB and expression of phogocyte-type NADPH-oxidase in mouse chondrocytic ATDC5 cells exposed to interleukin-1β2010

    • Author(s)
      Yoshimura K, et al.
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Application of Nitric Oxide
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Nitric oxide promotes odontoblastic differentiation2010

    • Author(s)
      Miyamoto Y, et al.
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Application of Nitric Oxide
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Carbonic anhydrase IX suppresses hypertrophic differentiation of chondrocytes2009

    • Author(s)
      丸山敏史(宮本洋一)
    • Organizer
      第29回 昭和歯学会 例会
    • Place of Presentation
      大田区
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨軟骨疾患のレドックス病態と抗酸化治療2009

    • Author(s)
      宮本洋一
    • Organizer
      日本学術振興会産学協力研究委員会レドックス生命科学第170委員会第21回研究会
    • Place of Presentation
      熊本
    • Year and Date
      2009-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Carbonic anhydrase IX suppresses hypertrophic differentiation of chondrocytes2009

    • Author(s)
      Maruyama T, et al.
    • Organizer
      第29回昭和歯学会例会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨軟骨疾患のレドックス病態と抗酸化治療2009

    • Author(s)
      宮本洋一
    • Organizer
      レドックス生命科学第170委員会 第21回研究会
    • Place of Presentation
      熊本県阿蘇郡南阿蘇村
    • Year and Date
      2009-07-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 炭酸脱水酵素IX型は軟骨細胞分化に関与する2009

    • Author(s)
      丸山敏史, 他
    • Organizer
      第74回日本インターフェロン・サイトカイン学会
    • Place of Presentation
      京都
    • Year and Date
      2009-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Monocarboxylate transporter-1は軟骨細胞においてIL-1.よって誘導される食細胞型NADPH-oxidaseの発現と細胞死を制御する2009

    • Author(s)
      吉村健太郎, 他
    • Organizer
      第74回日本インターフェロン・サイトカイン学会
    • Place of Presentation
      京都
    • Year and Date
      2009-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Monocarboxylate transporter-1は軟骨細胞においてIL-1βよって誘導される食細胞型NADPH-oxidaseの発現と細胞死を制御する2009

    • Author(s)
      吉村健太郎(宮本洋一)
    • Organizer
      第74回 日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 炭酸脱水酵素IX型は軟骨細胞分化に関与する2009

    • Author(s)
      丸山敏史(宮本洋一)
    • Organizer
      第74回 日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of carbonic anhydrase IX in chondrocyte differentiation2009

    • Author(s)
      Maruyama T, et al.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Monocarboxylate transporter-1は軟骨細胞における食細胞型NADPH-oxidaseの発現を制御する2009

    • Author(s)
      吉村健太郎, 他
    • Organizer
      第9回日本NO学会学術集会
    • Place of Presentation
      静岡
    • Related Report
      2011 Final Research Report
  • [Presentation] 軟骨細胞分化における炭酸脱水酵素IX型の役割2009

    • Author(s)
      丸山敏史, 他
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] Monocarboxylate transporter-1は軟骨細胞におけるIL-1.誘導性の食細胞型NADPH-oxidaseの発現と細胞死を制御する2009

    • Author(s)
      吉村健太郎, 他
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of carbonic anhydrase IX in chondrocyte differentiation2009

    • Author(s)
      Maruyama T, et al.
    • Organizer
      Yokosuka Science Festa 2009
    • Place of Presentation
      Yokosuka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of carbonic anhydrase IX in chondrocyte differentation2009

    • Author(s)
      吉村健太郎(宮本洋一)
    • Organizer
      Yokosuka Science Festa 2009
    • Place of Presentation
      Yokosuka, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Monocarboxylate transporter-1 is involved in the activation of NF-κB and expression of phagocyte-type NADPH-oxidase in mouse chondrocytes exposed to interleukin-1β2009

    • Author(s)
      吉村健太郎(宮本洋一)
    • Organizer
      31st Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Denver, Colorado, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Monocarboxylate transporter-1は軟骨細胞におけるIL-1β誘導性の食細胞型NADPH-oxidaseの発現と細胞死を制御する2009

    • Author(s)
      吉村健太郎(宮本洋一)
    • Organizer
      第27回 日本骨代謝学会 学術集会
    • Place of Presentation
      大阪市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨細胞分化における炭酸脱水酵素IX型の役割2009

    • Author(s)
      丸山敏史(宮本洋一)
    • Organizer
      第27回 日本骨代謝学会 学術集会
    • Place of Presentation
      大阪市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Monocarboxylate transporter-1は軟骨細胞における食細胞型NADPH-oxidaseの発現を制御する2009

    • Author(s)
      吉村健太郎(宮本洋一)
    • Organizer
      第9回 日本NO学会 学術集会
    • Place of Presentation
      静岡市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of carbonic anhydrase IX in chondrocyte differentiation2009

    • Author(s)
      丸山敏史(宮本洋一)
    • Organizer
      第32回 日本分子生物学会 年会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www10.showa-u.ac.jp/~oralbio/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www10.showa-u.ac.jp/~oralbio/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www10.showa-u.ac.jp/~oralbio/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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