| Project/Area Number |
21592376
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Ikuko 日本大学, 歯学部, 助手 (60459906)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 神経回路形成 / 味嗜好性 / 細胞接着分子 / Ig受容体 / 選択的スプライシング |
|---|
| Research Abstract |
Dscam, which encodes a neural Ig receptor, can generate more than 38,000 isoforms via alternative splicing. Dscam knock-down in taste cells induced loss of synapses between taste cells and secondary neurons. These flies showed reduced appetite or a decreased behavioral avoidance to bitter compounds. In contrast, the revertant flies with 22,000 isoforms showed indistinguishable feeding behavior with wildtype. Our results suggest that Dscam is essential for synapse formation in gustatory circuits and for the feeding behavior, but the full set of Dscam isoforms may not be required.
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