Role of Glial cell line-derived neurotrophic factor on the excitability of trigeminal ganglion neurons

• Project/Area Number: 21592377
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: The Nippon Dental University
• Principal Investigator: TAKEDA Mamoru 日本歯科大学, 生命歯学部, 准教授 (20227036)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 三叉神経節ニューロン / GDNF / パラクリン / 侵害受容 / パッチクランプ法 / 免疫組織化学法 / 電気泳動的投与法 / 細胞外記録法 / 生理学 / 脳、神経 / 三叉神経節 / 痛覚 / 神経栄養因子 / パッチクランプ

Research Abstract

Present study investigated that modulatory effect of Glial cell derived neurotrophic factor(GDNF) on the excitability of the trigeminal ganglion neurons under in vivo and in vitro conditions. The neuronal excitability of the nociceptive trigeminal ganglion neurons was modulated via paracrine mechanism in the soma or nerve terminals, and also this may contributes to development of trigeminal inflammatory hyperalgesia. Thus, GDNF receptor are the therapeutic molecular targets for treatment for trigeminal inflammatory hyperalgesia

Research Products

• [Journal Article] Glial cell line-derived neurotrophic factor modulates the excitability of nociceptive trigeminal ganglion neurons via a paracrine mechanism following inflammation. (2013)
  • Author(s): M. Takeda, M. Takahashi, N. Hara, S. Matsumoto
  • Journal Title: Brain, Behavior, and lmmunity Volume: 28 Pages: 100-107
  • DOI: 10.1016/j.bbi.2012.10.023
  • Peer Reviewed
• [Journal Article] Glial cell line-derived neurotrophic factor acutely modulates the excitability of rat small-diameter trigeminal ganglion neurons innervating facial skin (2010)
  • Author(s): Takeda M, Kitagawa J, Nasu M, Takahashi M, Iwata K, Matsumoto S
  • Journal Title: Brain Behav Immun Volume: 24 Pages: 72-82
• [Journal Article] Glial cell line-derived neurotrophic factor acutely modulates the excitability of rat small-diameter trigeminal ganglion neurons innervating facial skin. (2010)
  • Author(s): Takeda M, Kitagawa J, Nasu M, Takahashi M, Iwata K, Matsumoto S.
  • Journal Title: Brain Behavior Immunity Volume: 24 Pages: 72-82
  • Peer Reviewed
• [Presentation] 顔面皮膚を支配する小型三叉神経節ニューロンの興奮性に対するGDNFの急性修飾効果 (2010)
  • Author(s): 武田守、北川純一、那須優則、高橋誠之、岩田幸一、松本茂二
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2010-09-20
• [Presentation] Glial cell line-derived neurotrophic factor acutely modulates the excitability of rat small-diameter trigeminal ganglion neurons innervating facial skin. (2010)
  • Author(s): Takeda M, Kitagawa J, Nasu M,Takahashi M,Iwata K, Matsumoto S.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2010-09-02
• [Presentation] Glial cell line-derived neurotrophic factor acutely modulates the excitability of rat small-diameter trigeminal ganglion neurons innervating facial skin (2010)
  • Author(s): Takeda M, Kitagawa J, Nasu M, Takahashi M, Iwata K, Matsumoto S
• [Presentation] 顔面皮膚を支配する小型三叉神経節ニューロンの興奮性に対するGDNFの効果 (2010)
  • Author(s): 武田守、北川純一、那須優則岩田幸一、松本茂二