| Project/Area Number |
21592378
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
|
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Naoyuki 松本歯科大学, 総合歯科医学研究所, 教授 (90119222)
NINOMIYA Tadashi 松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 破骨細胞 / 骨吸収 / 天然有機化合物 / 抗癌剤 / 抗がん剤 |
|---|
| Research Abstract |
Arctigenin, an anti-tumor compound, is a plant-derived natural molecule. We find that arctigenin inhibits osteoclast formation and function. In RANKL-induced osteoclastogenesis arctigenin markedly represses the transcriptional activity of NFATc1.Our results suggest that a novel mechanism of NFATc1 in its transcriptional regulation, that is different from a known inhibitory mechanism by which NFATc1 is retained in the cytosol.
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