| Project/Area Number |
21592383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
ISHIKAWA Makoto 北海道大学, 北海道大学病院, 准教授 (10202970)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHINO Fumihiro 北海道大学, 大学院・歯学研究科, 准教授 (50301891)
SHINNDOU Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
HIDA Kyouko 北海道大学, 大学院・歯学研究科, 特任准教授 (40399952)
KITAMURA Tetsuya 北海道大学, 大学院・歯学研究科, 助教 (00451451)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔がん / ARE-mRNA / HuR / pp32 / pp32r1 / ノックダウン / 足場非依存性増殖能 / 浸潤能 |
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| Research Abstract |
In this study, we examined whether RNA binding proteins such as pp32 and HuR have oncogenic activity. AU-rich element(ARE) containing mRNA and HuR were exported to the cytoplasm of oral cancer cells. Although pp32 has potential to degrade HuR in the cytoplasm of cells, pp32r1 failed to do it. These results indicate that pp32r1 inhibits the degradation of HuR to stabilize ARE-mRNA and to transform cells
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