Immune regulation of oral disease by co-signal molecule B7-H3 and the novel receptor.
Project/Area Number |
21592385
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
|
Research Institution | Dokkyo Medical University (2010-2011) Tokyo Medical and Dental University (2009) |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
AZUMA Miyuki 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (90255654)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 免疫 / 感染 / 炎症 / ヒト免疫応答 / 補助シグナル / B7-H3 / TLT2 / 抗腫瘍免疫 / Tlt2 |
Research Abstract |
Co-signal molecules play important roles in positively or negatively regulate cell responses. We previously reported that new cosignal ligand murine B7-H3 and the receptor TLT-2 enhance T cell responses. Here we investigate the precise mechanisms and found, in human system, B7-H3 upregulate T cell responses through the ligation with TLT-2, too. We also clarified TLT-2 upregulates anti-tumor immunity through the enhancement of cytotoxicity by CD8^+T cells. These suggest that B7-H3.TLT-2 enhances anti-tumor immunity and imply that strong or continuous B7-H3.TLT-2 signaling lowers TLT-2.
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Report
(4 results)
Research Products
(11 results)