Analysis of miRNA expression profiles and mechanism of epigenetics in rat tongue carcinogenesis

• Project/Area Number: 21592393
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Asahi University (2010-2011); Kagoshima University (2009)
• Principal Investigator: TANUMA Jun-ishi 朝日大学, 歯学部, 教授 (20305139)
• Co-Investigator(Kenkyū-buntansha): SEMBA Ichiro 鹿児島大学, 医歯学総合研究科, 教授 (60145505)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ラット舌癌 / 舌癌モデル / メチル化 / 前癌病変 / hnRNP K / Real-time PCR / アレイ / 舌癌 / siRNA / ノチル化 / miRNA

Research Abstract

Oral cancer is one of the most commonly diagnosed malignancies worldwide. Its dismal five-year survival rate of. 50% has barely changed for decades. A better understanding of the molecular basis of tumorigenesis-with particular emphasis on disease initiation and progression-is needed to improve clinical outcomes, since this will facilitate the development of drugs and management strategies based on the specific genetic changes underpinning disease behaviors. MicroRNAs(miRNAs), a class of short non-coding RNAs that down-regulate gene expression, have been demonstrated to play essential roles in human cancers. miRNA deregulation has been observed in many tumor types and is implicated in oncogenic cell processes, including proliferation, survival, apoptosis, metastasis, and chemoresistance. In addition, miRNA alterations have been associated with specific clinical phenotypes such as disease progression or recurrence, development of metastases, and post-operative survival. Recent studies have explored the utility of miRNAs as diagnostic and prognostic tools and as potential therapeutic targets. Herein, we discuss miRNA biology and provide a summary of the key findings on the role of miRNAs in rat tongue carcinogenesis.

Research Products

• [Journal Article] Heterogeneous nuclear ribonucleopretein K as a new marker of early detection for 4NQO-indced rat tongue carcinogenesis (2012)
  • Author(s): Sakano Y, Tanuma J
  • Journal Title: 岐阜歯科学会 Volume: 39(1) Pages: 1-5
  • URL: http://scw.asahi-u.ac.jp/%7Egifusika/index.htm
  • Peer Reviewed
• [Journal Article] Heterogeneous nuclear ribonucleopretein K as a new marker of early detection for 4NQO-indced rat tongue carcinogenesis (2012)
  • Author(s): 坂野美栄、田沼順一
  • Journal Title: 岐阜歯科学会 Volume: 39(1) Pages: 1-6
  • Peer Reviewed
• [Journal Article] Basaloid squamous cell carcinoma of the tongue : a case report (2011)
  • Author(s): Matsui R, Tanuma J, Kwashima K, Miyahara M, Semba I, Sugihara K
  • Journal Title: Oral Medicine & Oral Pathology Volume: 15 Pages: 117-122
  • NAID: 130004509553
  • URL: http://www.jstage.jst.go.jp/browse/omp
  • Peer Reviewed
• [Journal Article] FGFR4 polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma (2010)
  • Author(s): Tanuma J, Izumo T, Hirano M, Oyazato Y, Hori F, Umemura E, Shisa H, Hiai H, Kitano M
  • Journal Title: Oncology Reports Volume: 23 Pages: 739-744
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20127014
  • Peer Reviewed
• [Journal Article] FGFR4 Gly388Arg polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma. (2010)
  • Author(s): Tanuma J, Izumo T, Hirano M, Oyazato Y, Hori F, Umemura E, Shisa H, Hiai H, Kitano M.
  • Journal Title: Oncology Reports Volume: 23 Pages: 739-744
  • Peer Reviewed
• [Journal Article] FGFR4 Gly388Arg polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma (2010)
  • Author(s): Tanuma J, Izumo T, Hirano M, Oyazato Y, Hori F, Umemura E, Shisa H, Hiai H, Kitano M.
  • Journal Title: Oncology Reports 23 Pages: 739-744
  • Peer Reviewed
• [Presentation] 原発性骨内扁平上皮癌の一例 (2012)
  • Author(s): 太田貴久、田沼順一, 他
  • Organizer: 第30回日本口腔腫瘍学会総会
  • Place of Presentation: 大宮(口演)
  • Year and Date: 2012-01-27
• [Presentation] hnRNPKと4NQO誘発ラット舌癌の前癌病変との関連 (2011)
  • Author(s): 坂野美栄、永山元彦、江原道子、志佐湍、北野元生、日合弘、田沼順一
  • Organizer: 第70回日本癌学会総会(English Oral Session)
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] 歯科基礎医学教育の分野間における現状、とその問題点 (2011)
  • Author(s): 田沼順一
  • Organizer: 第53回日本歯科基礎学会総会(シンポジウム)
  • Place of Presentation: 岐阜
  • Year and Date: 2011-10-01
• [Presentation] A case of odontogenic tumor (2011)
  • Author(s): 永山元彦、江原道子、田沼順一
  • Organizer: 第22回日本臨床口腔病理学会
  • Place of Presentation: 博多
  • Year and Date: 2011-08-25
• [Presentation] The combination of the FGFR4 and TP53 is prognostic factors for oral squamous cell carcinoma (2011)
  • Author(s): 田沼順一
  • Organizer: 第100回日本病理学会総会(Oral Session)
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-29
• [Presentation] The combination of the FGFR4 and TP53 is prognostic factors for oral squamous cell carcinoma (2010)
  • Author(s): 田沼順一
  • Organizer: 第52回歯科基礎医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-21
• [Presentation] FGFR4 Gly388Arg polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma. (2010)
  • Author(s): 田沼順一
  • Organizer: 歯科基礎医学会学術総会
  • Place of Presentation: 日本大学松戸歯学部(タワーホール船堀)
  • Year and Date: 2010-09-21
• [Book] 日常臨床の疑問に答えます (2012)
  • Author(s): 武藤晋也、田沼順一, 他
  • Total Pages: 180
  • Publisher: 医歯薬出版
• [Book] 日常臨床の疑問に答えますQ&A70 (2011)
  • Author(s): 武藤晋也、田沼順一, 他
  • Total Pages: 180
  • Publisher: 医歯薬出版
• [Remarks]
  • URL: http://scw.asahi-u.ac.jp/patho/
• [Remarks]
  • URL: http://scw.asahi-u.ac.jp/~patho/
• [Remarks]
  • URL: http://scw.asahi-u.ac.jp/~patho/