Establishment of optimal anti-angiogenic therapy against cancer of oral cavity

• Project/Area Number: 21592397
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: KOBAYASHI Masanobu 北海道医療大学, 看護福祉学部, 教授 (80241321)
• Co-Investigator(Kenkyū-buntansha): NAGAYASU Hiroki 北海道医療大学, 歯学部, 教授 (90265075)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 低酸素 / 血管新生 / 血管新生阻害剤 / 腫瘍増殖 / 遺伝子発現 / アドレノメジュリン / アドレノメジュリン阻害 / セリンスレオニンカイネース / pim-1 / アポトーシス / 口腔癌 / HIF-1 / adrenomedullin

Research Abstract

By the method of DNA microarray system, which can detect the genes expressed under under hypoxia, we identified the genes of adrenomedullin and pim-1.Tumor growth of cancer cells of oral cavity in a mouse model system and the angiogenesis stimulated by adrenomedullin was inhibited by adrenomedullin-antagonist.

Research Products

• [Journal Article] P53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5 (2012)
  • Author(s): Kobayashi T, et al
  • Journal Title: Int J Cancer Volume: 128 Pages: 304-318
  • Peer Reviewed
• [Journal Article] P53 transactivation is involved in the antiproliferative activity of the putativetumor suppressor RBM5 (2011)
  • Author(s): Kobayashi T, Ishida J, Musashi M, Ota S, Yoshida T, Shimizu Y, Chuma M, Kawakami Asaka M, Tanaka J, Imamura M, Kobayashi M, H, Itoh H, Edamatsu H, Sutherland LC, Brachmann RK.
  • Journal Title: Int J Cancer Volume: 128 Pages: 304-318
  • Peer Reviewed
• [Journal Article] Adrenomedullin antagonist suppresses in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization (2010)
  • Author(s): Tsuchiya K, Hida K, Hida Y, Muraki C, Ohga N, Akino T, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T, Shinohara N, Nonomura K, Kobayashi M.
  • Journal Title: Int J Oncol Volume: 36 Pages: 1379-86
  • Peer Reviewed
• [Journal Article] Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization. (2010)
  • Author(s): Tuchiya K, et al.
  • Journal Title: Int J Oncol Volume: 36 Pages: 1379-1386
  • Peer Reviewed
• [Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5. (2010)
  • Author(s): Kobayashi T, et al.
  • Journal Title: Int J Cancer Volume: (EPUB 電子書籍)
  • Peer Reviewed
• [Journal Article] Pim-1 plays a pivotal role in hypoxia-induced chemoresistance (2009)
  • Author(s): Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Yeung SC, Lee MH.
  • Journal Title: Oncogene Volume: 28 Pages: 2581-92
• [Journal Article] Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation (2009)
  • Author(s): Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, S-C Yeung S-C and Lee M-H.
  • Journal Title: Am J Pathol Volume: 175 Pages: 400-11
  • Peer Reviewed
• [Journal Article] Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells (2009)
  • Author(s): Onuma K, Sato Y, Ogawara S, Shirasawa N, Kobayashi M, Yoshitake J, Yoshimura T, Iigo M, Fujii J and Okada F.
  • Journal Title: Am J Pathol Volume: 175 Pages: 2171-2183
  • Peer Reviewed
• [Journal Article] Pim-1 plays a pivotal role in hypoxia-induced chemoresistance. (2009)
  • Author(s): Chen j, et al.
  • Journal Title: Oncogene 28 Pages: 2581-2592
  • Peer Reviewed
• [Journal Article] Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation, (2009)
  • Author(s): Chen j, et al.
  • Journal Title: Am J pathol 175 Pages: 400-411
  • Peer Reviewed