Fundamental and clinical assessment of F-18 Choline as a new cancer tracer for PET
Project/Area Number |
21592398
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | Iwate Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TERASAKI Kazunori 岩手医科大学, 医学部, 講師 (60285632)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | PET / 18F-コリン / FDG-PET / 放射線 / 歯学 / 口腔癌 / choline / 癌 / Choline |
Research Abstract |
This study evaluated the potential usefulness of[^<18> F] Choline as a new cancer tracer for PET. The uptake of[^<18> F] Choline and[^<18> F] FDG are cell cycle dependent, are associated with the proliferative activity of the tumor seen during PET imaging. The average SUVs of[^<18> F] FDG for the gingival cancer infiltrated jawbone was markedly higher than that for the tongue. The average SUVs of[^<11> C] or[^<18> F] Choline were showing no significant difference between the tongue and gingival cancer, and the same level as[^<18> F] FDG uptake for the tongue cancer. It seems that[^<18> F] Choline is not well incorporated to the osteogenetic cell and the osteoclast related to bone metabolism but accumulation for the cancer cells.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Preoperative central benzodiazepine receptor binding potential and cerebral blood flow images on SPECT predict development of new cerebral ischemic events and cerebral hyperperfusion after carotid endarterectomy2011
Author(s)
Sato Y., Ogasawara K., Kuroda H., Suzuki T., Chida K., Fujiwara S., Aso K., Kobayashi M., Yoshida K., Terasaki K., Ogawa A.
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Journal Title
Journal of Nuclear Medicine
Volume: 52
Pages: 1400-1407
Related Report
Peer Reviewed
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[Journal Article] Brain temperature measured using proton MR spectroscopy detects cerebral hemodynamic impairment in patients with unilateral chronic major cerebral artery steno-occlusive disease : comparison with positron emission tomography2009
Author(s)
Ishigaki D., Ogasawara K., Yoshioka Y., Chida K., Sasaki M., Fujiwara S., Aso K., Kobayashi M., Yoshida K., Terasaki K., Inoue T., Ogawa A.
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Journal Title
Stroke
Volume: 40
Pages: 3012-3016
Related Report
Peer Reviewed
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