| Project/Area Number |
21592401
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
MAENO Masao 日本大学, 歯学部, 教授 (60147618)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Naoto 日本大学, 歯学部, 教授 (10226532)
KAWATO Takayuki 日本大学, 歯学部, 講師 (50386075)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 顎関節症 / インターロイキン-17 / 骨芽細胞 / 破骨細胞前駆細胞 / 骨吸収 / 軟骨細胞 / 軟骨基質タンパク代謝 / IL-17 / MMP / TIMP / CD4^+T細胞 / PGE_2 / IL-17A / 破骨細胞 / 骨吸収関連酵素 / 炎症性サイトカイン / プロスタグランジンE2 / セレコキシブ / 細胞分化 / 炭酸脱水酵素II型 / カテプシンK / マトリックス金属プロテアーゼ-9 |
|---|
| Research Abstract |
We examined the effects of IL-17on bone and cartilage destruction supposing temporomandibular joint disorder. The osteoclast differentiation and function of mature osteoclasts were suppressed in the direct stimulation by IL-17A to osteoclast precursors, whereas they were induced in the indirect stimulation via osteoblasts. IL-17A promoted the production of extracellular matrix proteins in osteoblasts. In addition, our results suggested that IL-17F suppresses the direction of synthesis in cartilage matrix protein metabolism, whereas it promotes the direction of destruction in the metabolism by chondrocytes.
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