Role of SPARC on malignant phenotype of oral squamous cell carcinoma
| Project/Area Number |
21592403
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Ohu University (2010-2011)
Kanagawa Dental College (2009) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OZAWA Shigeyuki 神奈川歯科大学, 歯学部, 助教 (40434394)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | SPARC / 癌 / 肺転移 / ノックアウトマウス / 白内障 / 肺 / C3H / オステオネクチン / 転移 / 浸潤 / 口腔扁上皮癌 |
|---|
| Research Abstract |
Here we established new SPARC knock out mouse on C3H strain from MF strain by back crossing method. Using microarray technique, expression of 6 kinds of gene such as Camp, Ngp, Ig-., Saa3, Gpr84, Ptk6 was induced in the lung of SPARC knock our mice. These were suggested to be candidate genes associating lung metastasis of cancer.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] 学校法人神奈川歯科大学の学生・職員における喫煙経験と性・年齢,学生の所属,職員の職種,健康状態,および喫煙に対する知識・意識との関係2011
Author(s)
山本龍生, 加藤靖正, 菅谷彰, 塚本秀人, 辻本勝美, 中村澄夫, 林田丞太, 町田宏夫, 平田幸夫
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Journal Title
神奈川歯学
Volume: 46
Pages: 57-64
Related Report
Peer Reviewed
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[Journal Article] Heterozygous mutation (G/G→G/A) at 2607 is closely associated with increase in EGFR copy number and mRNA half life but impaired EGFR protein synthesis in squamous cell carcinoma of the head and neck-implication to the gefitinib efficacy-.2010
Author(s)
Nakazaki, K., Kato, Y., Taguchi, T., Inayama, Y., Ishiguro, Y., Tsukuda, M.
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Journal Title
Oncology Letters
Volume: 1
Pages: 1017-1020
Related Report
Peer Reviewed
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[Journal Article] Functional characterization of proximal promoter of gene for human chemokine BRAK/CXCL14.2010
Author(s)
Komori, R., Ozawa, S., Kato, Y., Shinji, H., Kimoto, S., Hata, RI.
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Journal Title
Biomedical Research
Volume: 31
Pages: 123-131
Related Report
Peer Reviewed
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[Journal Article] Restoration of BRAK/CXCL14 gene expression by gefitinib is associated with antitumor efficacy of the drug in head and neck squamous cell carcinoma2009
Author(s)
Ozawa S, Kato Y, Ito S, Komori R, Shiiki N, Tsukinoki K, Ozono S, Maehata Y, Taguchi T, Imagawa-Ishiguro Y, Tsukuda M, Kubota E, Hata R
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Journal Title
Cancer Science
Volume: 100
Issue: 11
Pages: 2202-2209
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Analysis of promoter region of human BRAK/CXCL14 in SCC cells.2011
Author(s)
Komori, R., Ozawa, S., Kato, Y., Maehata, Y., Shinji, H., Hata, R.-I, Kimoto, S.
Organizer
The International Association for Dental Research
Place of Presentation
San Diego, CA, USA
Related Report
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[Presentation] 習慣的喫煙経験と学生の学科,職員の職種,健康状態,喫煙の知識・意識との関係2010
Author(s)
山本龍生, 加藤靖正, 菅谷彰, 菅原光則, 田口利秋, 塚本秀人, 辻本勝美, 長尾健, 中村澄夫, 林弘之, 林田丞太, 町田宏夫, 米田睦夫, 平田幸夫
Organizer
神奈川歯科大学学会第45回総会
Place of Presentation
横須賀
Related Report
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