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Development of oral health-related indices for identifying individuals with increased risk of ischemic cardiovascular diseases

Research Project

Project/Area Number 21592404
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionMatsumoto Dental University

Principal Investigator

TAGUCHI Akira  松本歯科大学, 歯学部, 教授 (70243582)

Co-Investigator(Kenkyū-buntansha) YOSHINARI Nobuo  松本歯科大学, 歯学部, 教授 (20231699)
HIGASHI Yukihito  広島大学, 原爆放射線医科学研究所, 教授 (40346490)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords口腔衛生 / スクリーニング / 歯周病 / 梗塞 / 心臓血管疾患 / 予防医学 / かくれ脳梗塞 / MRI / 梗塞性心臓血管病変 / エックス線写真 / 脳梗塞
Research Abstract

Many studies have demonstrated significant association between poor oral health and increased risk of ischemic cardiovascular diseases. In this study, we evaluated the association between poor oral health and silent lacuna infarction. As the results, we found no clear association between them, suggesting that poor oral health may influence on large blood vessel but not small blood vessel in the brain.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (33 results)

All 2012 2011 2010 2009

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (11 results) Book (7 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Diagnosis of osteoporosis on dental panoramic radiographs using support vector machine in computer-aided system2012

    • Author(s)
      Kavitha MS, Asano A, Taguchi A, Kurita T, Sanada M
    • Journal Title

      BMC Medical Imaging

      Volume: 12 Issue: 1 Pages: 1-1

    • DOI

      10.1186/1471-2342-12-1

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computer-aided system for cortical width measurement of the mandible on dental panoramic radiographs to identify osteoporosis2012

    • Author(s)
      Kavitha MS, Samopa, F, Asano A, Taguchi A, Sanada M
    • Journal Title

      J Investig Clin Dent

      Volume: 3 Issue: 1 Pages: 36-44

    • DOI

      10.1111/j.2041-1626.2011.00095.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone mass of the mandible and the risk of breast cancer among Japanese postmenopausal women2012

    • Author(s)
      Taguchi A, Ohtsuka M, Nakamoto T, Suei Y, Tanimoto K, Kataoka T
    • Journal Title

      Breast J

      Volume: 18 Issue: 1 Pages: 93-94

    • DOI

      10.1111/j.1524-4741.2011.01193.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Geranyl-geranylacetone, heat shock protein 90/AMP-activated protein kinase/endothelial nitric oxide synthase/nitric oxide pathway, and endothelial function in humans2012

    • Author(s)
      Higashi Y(11人中11番目)
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Issue: 1 Pages: 153-60

    • DOI

      10.1161/atvbaha.111.237263

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autologous bone-marrow mononuclear cell implantation reduces long-term major amputation risk in patients with critical limb ischemia : A comparison of atherosclerotic peripheral arterial disease and buerger disease2011

    • Author(s)
      Taguchi A(16人中13番目), Higashi Y(16人中16番目)
    • Journal Title

      Circ Cardiovasc Interv

      Volume: 4 Issue: 1 Pages: 15-25

    • DOI

      10.1161/circinterventions.110.955724

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Japanese young adults with undetected low skeletal bone density using panoramic radiographs2011

    • Author(s)
      Taguchi A(12人中1番目), Yoshinari N(12人中11番目)
    • Journal Title

      Dentomaxillofac Radiol

      Volume: 40 Issue: 3 Pages: 154-9

    • DOI

      10.1259/dmfr/30045588

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ROCK Study Group. Rho-associated kinase activity, endothelial function, and cardiovascular risk factors2011

    • Author(s)
      Higashi Y(14人中14番目)
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 31 Issue: 10 Pages: 2353-9

    • DOI

      10.1161/atvbaha.111.227892

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Japanese young adults with undetected low skeletal bone density using panoramic radiographs2011

    • Author(s)
      Taguchi A, et al. (第1著者)
    • Journal Title

      Dentomaxillofac Radiol

      Volume: 40 Pages: 154-159

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MR T2-weighted IDEAL water imaging for assessing changes in masseter muscles caused by low-level static contraction2010

    • Author(s)
      Taguchi A(13人中2番目), Yoshinari N(13人中7番目)
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod

      Volume: 109 Issue: 6 Pages: 908-16

    • DOI

      10.1016/j.tripleo.2009.12.024

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alveolar density measurement and bisphosphonate-related osteonecrosis of the jaws2010

    • Author(s)
      Taguchi A
    • Journal Title

      Osteoporos Int

      Volume: 5 Issue: 5 Pages: 827-827

    • DOI

      10.1007/s00198-009-1094-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Triage screening for osteoporosis in dental clinics using panoramic radiographs2010

    • Author(s)
      Taguchi A
    • Journal Title

      Oral Dis

      Volume: 16 Issue: 4 Pages: 316-327

    • DOI

      10.1111/j.1601-0825.2009.01615.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bisphosphonate-Related Osteonecrosis of the Jaw2010

    • Author(s)
      Yoneda T, Hagino H, Sugimoto T, Ohta H, Takahashi S, Soen S, Taguchi A
    • Journal Title

      J Bone Miner Metab

      Volume: 28 Issue: 4 Pages: 365-383

    • DOI

      10.1007/s00774-010-0162-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial function in subjects with isolated low HDL cholesterol : role of nitric oxide and circulating progenitor cells2010

    • Author(s)
      Higashi Y, Matsuoka H, Umei H, Sugano R, Fujii Y, Soga J, Kihara Y, Chayama K, Imaizumi T
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 298 Issue: 2 Pages: E202-E209

    • DOI

      10.1152/ajpendo.00394.2009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Triage screening for osteoporosis in dental clinics using panoramic radiographs2010

    • Author(s)
      Taguchi A
    • Journal Title

      Oral Diseases 16

      Pages: 316-327

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔と骨粗鬆症との関わり-動脈硬化を交えて2011

    • Author(s)
      田口明
    • Organizer
      第10回信州骨粗鬆症セミナー
    • Place of Presentation
      ホテルブエナビスタ(松本市)(招待講演)
    • Year and Date
      2011-07-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Panoramic radiography measure and silent lacunar infarction2011

    • Author(s)
      Taguchi A, Miki M, Migita K, Higashi Y, Yoshinari N
    • Organizer
      The 18^<th> International Congress of Dento-maxillofacial Radiology
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2011-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯科放射線学による予防医学の推進-骨粗鬆症スクリーニング法開発への道のりと動脈硬化、乳癌スクリーニングへの展望-2011

    • Author(s)
      田口明
    • Organizer
      第44回新潟歯学会総会
    • Place of Presentation
      新潟大学歯学部(新潟市)(招待講演)
    • Year and Date
      2011-04-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Association of tooth loss with silent lacunar infarction2011

    • Author(s)
      Taguchi A, Miki M, Migita K, Higashi Y, Yoshinari N
    • Organizer
      IADR/AADR/CADR 89^<th> General Session and Exhibition
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-03-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Panoramic radiography measure and silent lacunar infarction2011

    • Author(s)
      Taguchi A, et al
    • Organizer
      The 18th International Congress of Oral and Maxillo-Facial Radiology
    • Place of Presentation
      広島国際会議場(広島市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Association of tooth loss with silent lacunar infarction2011

    • Author(s)
      Taguchi A, et al.
    • Organizer
      IADR/AADR/CADR 89th General Session and Exhibition
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Detection of Japanese young adults with undetected low skeletal bone density using panoramic radiographs2010

    • Author(s)
      Taguchi A, Sugino N, Osanai H, Uchida K
    • Organizer
      The 8^<th> Asian Congress of Oral and Maxillo-Facial Radiology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Bone mass of the mandible and the risk of breast cancer among Japanese postmenopausal women2010

    • Author(s)
      Taguchi A, Suei Y, Tanimoto K, Kataoka T
    • Organizer
      The 8^<th> Asian Congress of Oral and Maxillo-Facial Radiology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Screening for osteoporosis in dental clinics by panoramic radiographs2010

    • Author(s)
      Taguchi A
    • Organizer
      World Health Organization(WHO) International Symposium for Global Oral Health Science Niigata 2010
    • Place of Presentation
      Niigata
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Evaluation of bone quantity and quality of the jaws-imaging modalities and biochemical markers of bone quality2010

    • Author(s)
      Taguchi A
    • Organizer
      ICOI(International Congress of Oral Implantologist) European Symposium
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2010-04-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Diagnosis of osteoporosis on panoramic radiographs2009

    • Author(s)
      Taguchi A
    • Organizer
      17th International Congress of Oral and Maxillo-Facial Radiology
    • Place of Presentation
      Amsterdam
    • Year and Date
      2009-07-01
    • Related Report
      2009 Annual Research Report
  • [Book] エックス線写真処理ビスフォスフォネート製剤による顎骨異常の画像所見,金田隆編著Q & Aで学ぶ歯科放射線学: SBOs講義2011

    • Author(s)
      田口明
    • Total Pages
      233
    • Publisher
      学建書院
    • Related Report
      2011 Final Research Report
  • [Book] 骨粗鬆症-新たなる骨折を防ぐ最新の治療戦略VIII治療戦略と関連問題: 2.関連問題-顎骨壊死、SSBT(骨代謝回転の過剰抑制)と非典型骨折.骨粗鬆症治療におけるビスフォスフォネート製剤関連顎骨骨髄炎・顎骨壊死問題.遠藤直人編集別冊整形外科2011

    • Author(s)
      田口明, 上村幹男
    • Publisher
      南江堂
    • Related Report
      2011 Final Research Report
  • [Book] Q&Aで学ぶ歯科放射線学:SBO s講義2011

    • Author(s)
      田口明(分担)
    • Publisher
      学建書院
    • Related Report
      2011 Annual Research Report
  • [Book] 顎のパノラマX線写真から骨粗鬆症は診断できますか?また、骨粗鬆症と歯の喪失に関係があるか教えてください.西沢良記,中村利孝監修かかりつけ医でみる骨粗鬆症Q & A2010

    • Author(s)
      田口明
    • Publisher
      先端医学社
    • Related Report
      2011 Final Research Report
  • [Book] Chapter 7 : Implications of systemic osteoporosis on oral health. Dumitrescu AL editor, Etiology and Pathogenesis of Periodontal Disease2010

    • Author(s)
      Inagaki K
    • Publisher
      Springer-Verlag Berlin Heidelberg
    • Related Report
      2011 Final Research Report
  • [Book] 第8編歯科領域の画像:第8章X線画像による各種診断法.石田隆行,桂川茂彦,藤田広志監修.医用画像ハンドブック2010

    • Author(s)
      田口明
    • Publisher
      オーム社
    • Related Report
      2011 Final Research Report
  • [Book] 医用画像ハンドブック(分担).田口明.第8編 歯科領域の画像:第8章X線画像による各種診断法2010

    • Author(s)
      田口明
    • Publisher
      株式会社オーム社
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨粗鬆症診断支援装置及び骨粗鬆症診断プログラム2011

    • Inventor(s)
      浅野晃,ムトゥスバシュカヴィタ,リリャン,フェブリリヤンサモパ,田口明
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      2011-003987
    • Filing Date
      2011-01-12
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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