| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Molecular biological analysis was performed to engineer dental pulp tissues with normal immune systems in rat molar. First, I identify that resident macrophages are one of the key functions to manage during dental initiate dental pulp inflammation. Second, I demonstrate the two types of macrophage lineage cells in the engineered pulp tissues. These macrophage subpopulations distribute with regional variations and show different activation levels in different areas of engineered tissues to maintain the engineered dental pulp tissues. Taken together, these results strongly suggested a possibility to engineer dental pulp tissue with normal immune systems.
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