Molecular biological analysis for engineering of dental pulp tissues with normal immune systems
| Project/Area Number |
21592411
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Niigata University (2010-2011)
Tokyo Medical and Dental University (2009) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯内療法 / 歯周組織 / 歯髄 / マクロファージ / 組織再生 / レーザーキャプチャーマイクロダイゼクション / 抗原提示細胞 / 幹細胞 / 再生医学 / 免疫学 / ラット / 中枢神経 / 血管新生 |
|---|
| Research Abstract |
Molecular biological analysis was performed to engineer dental pulp tissues with normal immune systems in rat molar. First, I identify that resident macrophages are one of the key functions to manage during dental initiate dental pulp inflammation. Second, I demonstrate the two types of macrophage lineage cells in the engineered pulp tissues. These macrophage subpopulations distribute with regional variations and show different activation levels in different areas of engineered tissues to maintain the engineered dental pulp tissues. Taken together, these results strongly suggested a possibility to engineer dental pulp tissue with normal immune systems.
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Report
(4 results)
Research Products
(97 results)
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[Presentation] Endothelial Cell-initiated Signalling Events : Targets for Therapy and Potential Biomarkers in Head and Neck Cancer2011
Author(s)
Jacques Nor, Tomoatsu kaneko, Kristy Warner, Kathleen Neiva, Benjamin Zeitlin, Naoki Ashimori, Atsushi Imai, Zhihong Dong, Frank Worden, Shaomeng Wang
Organizer
NCI Translational Science Meeting 2011
Place of Presentation
Washington Marriott Wardman Hotel, Washington DC
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[Book] Formatex Research Center2010
Author(s)
Kaneko T, Okiji T, Kaneko
Total Pages
2199
Publisher
Microscopy Science, Technology, Applications and Educationvolume 3.(Laser capture microdissection from formaldehyde-ffixated and demineralized paraffin embedded tissues.)
Related Report
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