A study on the mechanisms of tissue repair and regeneration of dentin-pulp complex
| Project/Area Number |
21592417
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIBA Nagako 新潟大学, 医歯学総合病院, 講師 (10323974)
SHIGETANI Yoshimi 新潟大学, 医歯学系, 助教 (80397132)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 象牙質・歯髄複合体 / 修復・再生 / 歯髄組織幹細胞 / 象牙芽細胞 / 組織培養 / Thy-1 / 覆髄材 / MTA / 非コラーゲン性タンパク / TR-PCR / 組織培養法 / αSMA / 半導体レーザー |
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| Research Abstract |
The aim of this study was to elucidate cellular events during pulp tissue repair and reparative dentin formation after tooth injury. The up-regulation ofα-smooth muscle actin(SMA) was characteristically observed in fibroblastic cells in an organ culture system of rat molar. Thy-1-positive dental pulp cells localized in the subodontoblastic layer had the ability to differentiate into hard tissue-forming cells. Theα-SMA-positive and/or Thy-1-positive cells may play a role in tissue repair and regeneration of dental pulp.
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Report
(4 results)
Research Products
(61 results)
