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The analysis of function and localization of matrixmetalloproteinase in the process of forming tertiary dentin.

Research Project

Project/Area Number 21592419
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

ITOH Shousaku  大阪大学, 大学院・歯学研究科, 助教 (90360495)

Co-Investigator(Kenkyū-buntansha) YABUNE Toshiaki  大阪大学, 大学院・歯学研究科, 助教 (90423144)
ABE Makoto  大阪大学, 大学院・歯学研究科, 助教 (40448105)
TAKAHASI Yusuke  大阪大学, 大学院・歯学研究科, 助教 (60397693)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords修復象牙質 / MMPファミリー / in situ hydridization / MDPC-23 / 窩洞形成 / in situ hybridization / 骨芽細胞 / 石灰化 / 覆髄剤 / 硬組織産生細胞 / カルシウムセンシングレセプター / シグナル
Research Abstract

TIMP1, which promotes the mineralization of odontoblast and activates undifferentiated mesenchymal cells via Wnt/β-catenin pathway in the pulp after cavity preparation, might be one of a critical molecule for tertiary dentinogenesis and one of a candidate for a new" biological" pulp capping materials.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2012 2011 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results)

  • [Journal Article] Kruppel-like factor 4 regulates membranous and endochondral ossification2012

    • Author(s)
      Ikumi Michikami, Toshiya Fukushi, Mariko Tanaka, Hiroshi Egusa, Yoshinobu Maeda, Takashi Ooshima, Satoshi Wakisaka, Makoto Abe
    • Journal Title

      EXPERIMENTAL CELL RESEARCH

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kruppel-like factor 4 regulates membranous and endochondral ossification2012

    • Author(s)
      Michikami I, Fukushi T, Tanaka M, Egusa H, Maeda Y, Ooshima T, Wakisaka S, Abe M
    • Journal Title

      Experimental Cell Research

      Volume: 318(4) Issue: 4 Pages: 311-325

    • DOI

      10.1016/j.yexcr.2011.12.013

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An explanation of the mineralization mechanism in osteoblasts induced by calcium hydroxide2010

    • Author(s)
      成田寛子, 伊藤祥作
    • Journal Title

      Acta Biomaterialia 6

      Pages: 586-590

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規幹細胞集団における硬組織再生能の評価2011

    • Author(s)
      伊藤祥作、松下健太、池田峻、山本由美子、恵比須繁之
    • Organizer
      第134回日本歯科保存学会秋季学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 修復象牙質形成過程におけるTissue inhibitor of metalloprotease 1の発現誘導2011

    • Author(s)
      吉岡靖介、高橋雄介、今里聡、恵比須繁之
    • Organizer
      第134回日本歯科保存学会春季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨髄ストローマ細胞の骨芽細胞分化におけるLIFの機能解析2011

    • Author(s)
      松下健太、伊藤祥作、池田峻、恵比須繁之
    • Organizer
      第134回日本歯科保存学会春季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Effects of Calcium Hydroxide on Osteoblast Differentiation and Mineralization2010

    • Author(s)
      H. Nasa, S. Itoh, S. Imazato, S. Ebisu
    • Organizer
      第58回Japanese Association for Dental Research
    • Place of Presentation
      福岡
    • Year and Date
      2010-11-21
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 象牙質基質タンパク質分解産物が歯髄細胞に与える影響2010

    • Author(s)
      高橋雄介、吉岡靖介、今里聡、恵比須繁之
    • Organizer
      第133回日本歯科保存学会秋季学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-10-29
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 高度骨再生能を有する新規細胞集団精製法についての報告2010

    • Author(s)
      伊藤祥作、松下健太、恵比須繁之
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-23
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 高度骨再生能を有する新規細胞集団精製法についての報告2009

    • Author(s)
      伊藤祥作
    • Organizer
      第131回 日本歯科保存学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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