Study of biofilm elimination and regeneration of periapical lesion using in vitro periapical lesion defect model
| Project/Area Number |
21592428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Chiaki 九州歯科大学, 歯学部, 教授 (50265005)
OGAWA Yukio 九州歯科大学, 歯学部, 特別研修員 (50379989)
UENO Yoshiko 九州歯科大学, 歯学部, 特別研修員 (60536291)
TERASHITA Masamichi 九州歯科大学, 歯学部, 教授 (00118085)
NISHIHARA Tatsuji 九州歯科大学, 歯学部, 教授 (80192251)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯内療法学 / 半導体レーザー / 根尖性歯周炎 / バイオフィルム |
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| Research Abstract |
Objective. Photodynamic therapy has been expanded for use in endodontic treatment. The aim of this study was to investigate the antimicrobial effects of diode laser irradiation on endodontic pathogens in periapical lesions using an in vitro apical lesion model. Study Design. Enterococcus faecalis in 0.5% semisolid agar with a photosensitizer was injected into apical lesion area of in vitro apical lesion model.
The direct effects of irradiation with a diode laser as well as heat produced by irradiation on the viability of microorganisms in the lesions were analyzed. Results. The viability of E. faecalis was significantly reduced by the combination of a photosensitizer and laser irradiation. The temperature caused by irradiation rose, however, there were no cytotoxic effects of heat on the viability of E. faecalis.
Conclusion. Our results suggest that utilization of a diode laser in combination with a photosensitizer may be useful for clinical treatment of periapical lesions.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] 九州歯科大学附属病院保存治療科を受診した患者の初診時診査からみた歯内治療の現状2011
Author(s)
鷲尾絢子, 中川愛加, 西藤法子, 吉居慎二, 平田志津, 市丸美希, 永吉雅人, 矢野淳也, 諸冨孝彦, 寺下正道, 北村知昭
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Journal Title
日本歯内療法学会雑誌
Volume: 32巻
Pages: 206-211
NAID
Related Report
Peer Reviewed
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