| Project/Area Number |
21592433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
|
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| Research Institution | Nihon University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
OHSHIMA Mitsuhiro 奥羽大学, 薬学部, 教授 (30194145)
|
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| Co-Investigator(Renkei-kenkyūsha) |
ABIKO Yoshimitsu 日本大学, 松戸歯学部, 教授 (70050086)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 歯原性嚢胞 / 非外科的治療法 / 分子標的治療 / 受容体チロシンキナーゼ阻害剤 / 歯根嚢胞 / 角化嚢胞性歯原性腫瘍 / 分子標的治療薬 / 嚢胞由来線維芽細胞 / 細胞死 |
|---|
| Research Abstract |
To establish molecular targeted therapy for odontogenic cysts, a basic in vitro study was carried out. Fibroblasts originated from apical cyst and keratocystic odontogenic tumor were treated with various growth factor receptor kinase inhibitors, and the survival level of the cells was investigated. Since PD166866 and PD089828 induced effective fibroblast cell death, these receptor tyrosine kinase inhibitors may be candidate drugs for molecular targeted, non-surgical therapy for odontogenic cysts.
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