| Project/Area Number |
21592439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
ANAN Hisashi 福岡歯科大学, 歯学部, 教授 (80158732)
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| Co-Investigator(Kenkyū-buntansha) |
IZUMI Toshio 福岡歯科大学, 歯学部, 准教授 (40248547)
EIDA Taro 福岡歯科大学, 歯学部, 助教 (60425246)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 創傷治癒 / 再生医療 / bFGF / 生体活性ガラス / マクロファージ / BMP-2 / 修復象牙質 / 骨形成 / TGF-β1 / BMP / 再生療法 / 増殖因子 / BMP-4 / PCNA / 根尖病変 / IL-1α / IL-1β / TGF-1β / 骨創腔 |
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| Research Abstract |
Pulpotomy was performed in the mandibular first molars of rats, and then bFGF or VitapexR(VIT) containing calcium hydroxide were applied to the exposed pulp tissues. In the bFGF-treated rats, cells expressing TGF-β1 or BMP-2 rapidly increased in number, and newly formed reparative dentin was observed earlier and larger in amount than that seen in the VIT-treated rats. It is suggested that there may be a difference in the time and extent of expression of cytokine and growth factors between bFGF and VIT-treated rats.
Active new bone formation was observed in the bone defect with a combination of bFGF and Bioactive glass(BAG). It is speculated that BAG was a useful biomaterial with high bone conductivity.
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