| Project/Area Number |
21592464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
KOJO Tatsuro 九州歯科大学, 歯学部, 講師 (80153542)
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| Co-Investigator(Kenkyū-buntansha) |
HOSOKAWA Ryuji 九州歯科大学, 歯学部, 教授 (60211546)
NAKAMOTO Tetsuji 九州歯科大学, 歯学部, 准教授 (30514989)
MASAKI Chihiro 九州歯科大学, 歯学部, 助教 (60397940)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 遺伝子多型 / SNP / 遺伝子診断 / インプラント周囲炎 / 粘膜細胞 |
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| Research Abstract |
This study examined the association between implant failure and TNFα and IL-1β single nucleotide polymorphism(SNP) in Asian patients. Forty patients were divided into a test group with one or more implants that failed early(n=13) and a control group with healthy implants(n=27). Genotyping was performed by PCR-RFLP. In the implant analysis, the allele distribution of TNFα differed significantly between the two groups(p=0.02), and among the patients possessing both genotypes, i. e., allele T at TNFα and IL-1β, the difference between the control and test groups was significant(p=0.008). This study suggests that possessing both TNFα and IL-1β SNP constitutes a risk factor for implant failure in Asian patients.
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