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RE MOUTH ACTIVITIES INVOLVED IN THE PROCESS OF COGNITIVE DISORDERS?-IN SEARCH OF NEUROPATHOLOGIC ASSOCIATIONS-

Research Project

Project/Area Number 21592473
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthetic dentistry
Research InstitutionNihon University

Principal Investigator

NARITA Noriyuki  日本大学, 松戸歯学部, 准教授 (10155997)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords義歯治療 / 前頭前皮質 / 口腔関連 / 健康関連QOL / Mini-Mental State Examination / 咀嚼筋活動 / 咀嚼スコア / 近赤外分光法(NIRS) / 口腔関連QOL / 局部床義歯 / 前頭前野 / 咀嚼 / 咬合接触 / 摂食食品スコア / f-NIRS / 認知機能テスト / 摂取食品スコアー
Research Abstract

Denture wearing is considered to improve chewing ability, chewing comfort, and quality of life(QOL) in elderly individuals. In order to clarify the effects of denture treatment on activation of the prefrontal cortex, which is involved in higher cognitive functions, we investigated the efficacy of wearing a denture prosthesis from the aspects of cognitive and jaw functions, and related prefrontal cortex activity. Partially edentulous patients were enlisted as subjects. Functional near infrared spectroscopy(f-NIRS) was used to detect changes of cerebral blood flow in the prefrontal cortex area, while cognitive functions were examined using questionnaires(SF36 v2, OHIP-J, and MMSE : Mini-mental state examination), with jaw muscle EMG and motions activities simultaneously investigated. Masticatory scores were also used to evaluate subjective awareness and consciousness of chewing ability. Statistical comparisons were performed between data obtained while wearing and not wearing a denture prosthesis. Significant increases were seen in chewing-related jaw functions, including jaw motion, jaw muscle EMG, and prefrontal cortex activity, while masticatory scores were also significantly improved by wearing a partial denture prosthesis as compared with the non-wearing condition. Prefrontal cortex activity caused by a wearing denture prosthesis was significantly related to masticatory score and masticatory EMG activities. During the process of denture treatment, the scores of dental and physical QOL, and MMSE showed improving trends as compared to the pre-therapeutic conditions. Based on our findings, we consider that dental treatment with a denture prosthesis may help to improve not only masticatory jaw functions, but also cognitive ability, as shown by prefrontal cortex activation and cognitive scores for oral and physical QOL.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010 2009

All Journal Article (1 results) Presentation (14 results) Book (3 results)

  • [Journal Article] 歯科医学における顎口腔系のシステム神経科学/神経歯科学の意義2011

    • Author(s)
      成田紀之
    • Journal Title

      統計数理研究所研究リポート

      Volume: 258巻 Pages: 26-36

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Association between jaw functions and prefrontal cortex activity by wearing denture prosthesis2011

    • Author(s)
      N.NARITA
    • Organizer
      Society for Neuroscience (SfN)
    • Place of Presentation
      Washington, DC
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 部分歯列欠損患者の咀嚼時顎筋活動の協調性に関する検討-義歯装着の効果について-2011

    • Author(s)
      成田紀之
    • Organizer
      日本補綴歯科学会第120回記念学術大会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Association between jaw functions and prefrontal cortex activity by wearing denture prosthesis2011

    • Author(s)
      N. NARITA
    • Organizer
      Society for Neuroscience(SfN)
    • Place of Presentation
      Washington DC
    • Related Report
      2011 Final Research Report
  • [Presentation] 部分歯列欠損患者の咀嚼時顎筋活動の協調性に関する検討-義歯装着の効果について-2011

    • Author(s)
      成田紀之
    • Organizer
      日本補綴歯科学会
    • Place of Presentation
      広島
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト顎口腔機能のシステム評価-その基礎と臨床2010

    • Author(s)
      成田紀之
    • Organizer
      医学・工学における逆問題とその周辺(2)研究会
    • Place of Presentation
      東京(統計数理研究所)(特別講演)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 欠損補綴治療による咀嚼の改善と前頭前野の活動性2010

    • Author(s)
      神谷和伸, 他
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京(タワーホール船堀)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of Partial Denture Wearing on Dorsolateral Prefrontal Cortex Activation2010

    • Author(s)
      Narita N
    • Organizer
      88th IADR General Session
    • Place of Presentation
      Spain(Barcelona)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 局部床義歯装着による前頭前野の活動性の向上-若年健常者との比較検討から-2010

    • Author(s)
      成田紀之
    • Organizer
      日本補綴歯科学会第114回学術大会
    • Place of Presentation
      東京(東京ビッグサイト)
    • Year and Date
      2010-06-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 欠損補綴治療による咀嚼の改善と前頭前野の活動性2010

    • Author(s)
      成田紀之
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of Partial Denture Wearing on Dorsolateral Prefrontal Activation2010

    • Author(s)
      N. NARITA
    • Organizer
      International Association for Dental Research(IADR)
    • Place of Presentation
      Barcelona
    • Related Report
      2011 Final Research Report
  • [Presentation] 局部床義歯装着による前頭前野の活動性の向上-若年健常者との比較検討から-2010

    • Author(s)
      成田紀之
    • Organizer
      日本補綴歯科学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 義歯装着による咀嚼時の前頭前野の活性局在に関するf-NIRS研究2009

    • Author(s)
      成田紀之
    • Organizer
      日本補綴歯科学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 咀嚼にかかわる一次感覚運動皮質活動のf-NIRS計測2009

    • Author(s)
      成田紀之
    • Organizer
      日本顎口腔機能学会
    • Place of Presentation
      昭和大学(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 義歯装着による咀嚼時の前頭前野の活性局在に関するf-NIRS研究2009

    • Author(s)
      成田紀之
    • Organizer
      日本補綴歯科学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2009 Annual Research Report
  • [Book] Dentures Types, Benefits and Potential Complication, Chapter 3 Effects of Wearing Partial Denture Prosthesis on Jaw Functions and Associated Prefrontal Cortex Activity2012

    • Author(s)
      Noriyuki Narita
    • Publisher
      Nova Science Publishers
    • Related Report
      2011 Final Research Report
  • [Book] Dentures : Types, Benefits and Potential Complication, Chapter 3 : Effects of Wearing Partial Denture Prosthesis on Jaw Functions and Associated Prefrontal Cortex Activity(Noriyuki Narita))2012

    • Author(s)
      Noriyuki Narita
    • Publisher
      Nova Publishers(in press)
    • Related Report
      2011 Annual Research Report
  • [Book] 統計数理研究所共同研究リポート258 医学・工学における逆問題とその周辺(2)歯科医学における顎口腔機能のシステム神経科学/神経歯科学の意義2011

    • Author(s)
      成田紀之
    • Total Pages
      11
    • Publisher
      統計数理研究所
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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