Investigation of the inhibitory factors for osseointegration in the early stage of the implantation.
| Project/Area Number |
21592488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
HORIUCHI Rumi 北海道大学, 北海道大学病院, 助教 (10374274)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Atsuro 北海道大学, 大学院・歯学研究科, 教授 (20210627)
YAMAMOTO Satoru 北海道大学, 大学院・歯学研究科, 助教 (10344524)
HORIUCHI Msasataka 北海道大学, 大学院・薬学研究院, 助教 (90322825)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | オッセオインテグレーション / マイクロアレイ / チタンインプラント / Real time PCR |
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| Research Abstract |
We comprehensively evaluated by whole genome microarray analysis for the variation of gene organization around titanium implants were implanted in the femur in rats, and we compared gene expression in a rat model of acquired and non-acquired osseointegration. This study suggested that the expression of genes may be involved in bone formation in the establishment of osseointegration, but that the various genes expressed in a complex were assosiated with failure of osseointegration.
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Report
(4 results)
Research Products
(3 results)
