| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The objective of this study was to develop chitosan/hydroxyapatite(HAp) composite suitable for jaw regeneration, develop DDS technology for growth factors, and estimate bone formation and anti-cancer effects of the composites. By using the co-precipitation and porogen-leaching method, we developed a novel chitosan/HAp composite with various porosities, which was found to be mechanically flexible and easily formed into any desired shape. The composites with rhBMP-2 resulted in active bone formation. These results suggested that the composite was an effective material as a DDS carrier. Misexpressions of PRL-3 genes are implicated in the development of oral SCC. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. We plan to develop DDS materials which will act in the response with HOX genes expressions.
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