| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The aim of this study was to investigate the properties of hyaluronic acid gel, which is an important component of biofilms, in order to find any physicochemical conditions leading to the suppression of the quorum sensing. An antimicrobial permeated more effectively through the hyaluronic acid gel when the gel viscosity was lowered. Addition of basic(cationic) antimicrobial surfactants was especially effective to lower the gel viscosity. Those findings would lead to the tactical inhibition of infection using a disturbance of the quorum sensing by interrupting the diffusion of autoinducers through the biofilm.
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