| Project/Area Number |
21592523
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
IIDA Seiji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40283791)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
AIKAWA Tomonao 大阪大学, 歯学部附属病院, 講師 (00362674)
YAMACHIKA Eiki 岡山大学, 岡山大学病院, 講師 (10294422)
TAKAO Kana 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00448151)
MASUDA Tomotake 大阪大学, 歯学部附属病院, 医員
増田 友丈 大阪大学, 歯学部附属病院, 医員 (20510978)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 顎骨嚢胞 / 顎骨腫瘍 / 破骨細胞 / RANKL / TGF-b / TGF-beta / IL-lalpha / 骨吸収 / TGF-β |
|---|
| Research Abstract |
Jaw cyst and jaw benign tumor grow within a jawbone, resorbing surrounding jawbone. We studied how the osteoclast formation was activated which absorbs a bone how being activated in the process. As a result, it became clear that the cytokine, expressed by those lesions, induced promotes the osteoclast activating factor of the stromal fibroblasts. This pathway was suggested to be one of the mechanisms of the jawbone resorption and lesion-growth into the bone.
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