| Project/Area Number |
21592524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Medical College (2011)
University of Fukui (2009-2010) |
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Principal Investigator |
UENO Takaaki 大阪医科大学, 医学部, 教授 (60252996)
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| Co-Investigator(Kenkyū-buntansha) |
YAMACHIKA Eiki 岡山大学, 大学病院, 講師 (10294422)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 骨再生 / 成長因子 / マイクロCT / 血管誘導 / 骨髄細胞 / BMP / 血管形成 / 破骨細胞 / 骨芽細胞 / 骨吸収 / 血管内皮細胞 / 骨形成因子 / 組織学的観察 / 三次元微細構造観察 / BMP-2 / 骨形成タンパク / 骨髄未分化細胞 |
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| Research Abstract |
We investigated the osteogenic potential of a combination graft of autogenous bone marrow and bone morphogenetic protein(=BMP-2) in the rat calvarial defect. The newly formed bone was studied histologically and radiographically and compared with BMP-2 graft. Sixty days after grafting, the combination graft of autogenous bone marrow and BMP-2 showed new bone formation and no resorption of newly formed bone in the defect. The BMP-2 grafted in the defect showed bone formation and formed bone was resorbed at the edge of the defect. Total bone formation of the vombination of autogenous bone marrow and BMP-2 was obviously increased compared with BMP-2 graft. This result suggested that the newly formed vascularization was important event to increase and keep the volume of newly formed bone in the defect.
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