Analysis of epithelial integrity system in tumor invasion and metastasis of oral cancer
| Project/Area Number |
21592526
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAMATA Nobuyuki 広島大学, 大学院・医歯薬学総合研究科, 教授 (70242211)
TOBIUME Kei 広島大学, 大学院・医歯薬学総合研究科, 准教 (40350037)
SHIGEISHI Hideo 広島大学, 大学院・医歯薬学総合研究科, 助教 (90397943)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Shigehiro 広島大学, 大学院・医歯薬学総合研究科, 助教研 (70379882)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔癌 / 上皮間葉移行 / 癌の浸潤・転移 / p^63 / 上皮整合性 / 上皮・間葉移行 / p63 |
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| Research Abstract |
Epithelial-Mesencymal Transition(EMT) is involved in tumor invasion and metastasis of oral squamous cell carcinomas(SCCs). Snail, a transcription factor and EMT inducer, directs transcription of its target genes for the acquisition of EMT in SCC cells. We focused a process of loss of epithelial integrity among SCC cells during the EMT. For the investigation of that, we generated SCC cell pools of forced Snail expression by recombinant virus infection system. Almost the cells displayed constant expression of exogenous Snail, however, a small population of the cells underwent EMT. The cells on culture dish were given the migration area and were escalated into EMT. Immnocytochemistory and immnoblot analyses showed that loss of epithelial integrity and cell-cell contact were the last step of EMT process and the process was accelerated by distinct humoral factors.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Lymphangiogenesis and metastasis : Role of tumor-inducedlymphatic vessel activation in extramammary Paget' s disease2009
Author(s)
Hirakawa S, Detmar M, Kerjaschki D, Nagamatsu S, Matsuo K, Tanemura A, Kamata N, Higashikawa K, Okazaki H, Kameda K, Nishida-Fukuda H, Mori H, Hanakawa Y, Sayama K, Shirakata Y, Tohyama M, Tokumaru S, Katayama I, Hashimoto K
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Journal Title
Am JPathol
Volume: 175(5)
Pages: 2235-48
Related Report
Peer Reviewed
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