| Project/Area Number |
21592528
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAGAI Hirokazu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (50282190)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Youji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20200214)
NAKATA Akira 秋田大学, 医学部, 助教 (50400510)
SUGIYAMA Toshihiro 秋田大学, 医学部, 教授 (00127242)
TAMATANI Tetsuya 徳島大学, 病院, 講師 (30274236)
UCHIDA Daisuke 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (20335798)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 再生医学 / 歯の再生医療 / 間葉系幹細胞 / 歯学 / 移植・再生医療 |
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| Research Abstract |
In this study, we try to develop the tooth regenerative therapy applied to molecular mechanisms of epithelial-mesenchymal interactions in tooth morphogenesis. We used mesenchymal stem cells derived from human bone marrow or human adipose tissue for cell source of tooth regenerative therapy, and used low crystalline carbonate apatite for scaffold of tooth regenerative therapy. As a result, it was revealed that 1) mesenchymal stem cells have potency of odontoblastic differentiation, 2) carbonate apatite was resorbed by osteoclast in vivo, 3) mesenchymal stem cells cultured on carbonate apatite differentiated into osteoblastic cells.
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