| Project/Area Number |
21592535
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Toshiro 京都府立医科大学, 医学研究科・歯科口腔科学, 講師 (40347472)
AMEMIYA Takeshi 京都府立医科大学, 医学研究科・歯科口腔科学, 助教 (90398389)
AKAMATSU Yuki 京都府立医科大学, 医学研究科・歯科口腔科学, 助教 (40580733)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔外科一般(含病態検査学) / 移植・再生医療 / 再生医学 / 細胞・組織 / 歯学 / 臨床 |
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| Research Abstract |
Autologous oral mucosal epithelial sheets, which were cultivated on amniotic membrane, were used for the transplantation of oral mucosa after oral surgery(9 cases : mucocele ; oral leukoplakia ; pleomorphic adenoma ; lip neoplasm ; and fibroma of buccal mucosa). In 7 of these cases, a favorable post-transplant course was obtained with reproduced oral mucosa without abnormalities at the transplantation site. On the other hand, transplant approaches were not applicable in the remaining 2 cases, in which the diseased portion was removed, involving a substantial loss, suggesting the necessity of examining the appropriate selection of patients and surgical procedures for transplantation.
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