oral maxillofacial reconstruction using oral mucosal epithelial sheets

• Project/Area Number: 21592538
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: FUKADA Kenji 東京女子医科大学, 医学部, 講師 (70266815)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 口腔粘膜上皮シート / 温度応答性培養皿 / 細胞シート工学 / 口腔前庭拡張術 / 口腔前庭狭窄 / 顎骨再建

Research Abstract

We made dog stricture model of vestibulumoris and oral mucosal epithelial sheets using temperature-responsive culture dishes.
Autologous transplantation of these cell sheets was performed after vestibulumoris. The recovery of transplanted group is early compared with the control group, and the contracted scar of transplanted group is slightly smaller.