Establishment of inhibition of Oral cancer lymph node metastasis by suppressing lymphangiogenesis by transcription factor CSDA

• Project/Area Number: 21592541
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: MATSUMOTO Goichi 神奈川歯科大学, 歯学部, 准教授 (60199867)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: CSDA / 口腔癌 / リンパ節転移 / 血管新生 / リンパ管新生 / VEGFs / AP-1 / VEGF-A / VEGF-C / HRE / SRE / MMP / SCC

Research Abstract

Cold shock domain protein A(CSDA) is a DNA-binding protein that represses angiogenesis and lymphangiogenesis by directly binding to hypoxia response element(HRE) and serum response element(SRE). This study repots that overexpression of CSDA significantly inhibits the production of VEGF-A and VEGF-C in murine SCC cells. And CSDA overexpression inhibited tumor growth and lymphnode metastasis.

Research Products

• [Journal Article] NK4 gene therapy combined with cisplatin inhibits tumour growth and metastasis of squamous cell carcinoma (2011)
  • Author(s): Matsumoto G, Omi Y, Lee U, Kubota E, Tabata Y
  • Journal Title: Anticancer Res Volume: 31(1) Pages: 105-111
• [Journal Article] NK4 gene therapy combined with cisplatin inhibits tumor growth and metastasis of squamous cell carcinoma (2011)
  • Author(s): Matsumoto G, et al
  • Journal Title: Anticancer Research Volume: 31 Pages: 105-112
  • Peer Reviewed
• [Journal Article] Cold shock domain protein A(CSDA) overexpression inhibits tumor growth and lymph node metastasis in a mouse model of squamous cell carcinoma (2010)
  • Author(s): Matsumoto G, Yajima N, Saito H, Nakagami H, Omi Y, Lee U, Kaneda Y
  • Journal Title: Clin Exp Metastasis Volume: 27(7) Pages: 539-547
• [Journal Article] Cold shock domain protein A (CSDA) overexpression inhibits tumor growth and lymph node metastasis in a mouse modelof squamous cell carcinoma (2010)
  • Author(s): Goichi Matsumoto, et al.
  • Journal Title: Clinical & experimental metastasis Volume: 27 Pages: 539-547
  • Peer Reviewed
• [Presentation] BMP-2固定化多角体を用いた新規骨再生療法の開発 (2011)
  • Author(s): 松本剛一
  • Organizer: 第65回日本口腔科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-21
• [Presentation] Cold shock domain protein A(CSDA)はリンパ管新生を阻害しリンパ節転移を抑制する (2009)
  • Author(s): 松本剛一、久保田英朗
  • Organizer: 第33回日本頭頸部癌学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-06-10
• [Presentation] Cold shock domain protein A(CSDA) inhibits lymphnode metastasis via repression of lymphangiogenesis in squamous cell carcinoma (2009)
  • Author(s): Matsumoto G and Kubota E
  • Organizer: Second World Congress of the International Academic of Oral Oncology
  • Place of Presentation: Toronto
• [Remarks]
  • URL: http://kaken.nii.ac.jp/ja/p/21592541