Establishment of inhibition of Oral cancer lymph node metastasis by suppressing lymphangiogenesis by transcription factor CSDA
| Project/Area Number |
21592541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | CSDA / 口腔癌 / リンパ節転移 / 血管新生 / リンパ管新生 / VEGFs / AP-1 / VEGF-A / VEGF-C / HRE / SRE / MMP / SCC |
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| Research Abstract |
Cold shock domain protein A(CSDA) is a DNA-binding protein that represses angiogenesis and lymphangiogenesis by directly binding to hypoxia response element(HRE) and serum response element(SRE). This study repots that overexpression of CSDA significantly inhibits the production of VEGF-A and VEGF-C in murine SCC cells. And CSDA overexpression inhibited tumor growth and lymphnode metastasis.
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Report
(4 results)
Research Products
(8 results)
