Development of diagnostic panel of oral cancer cell properties by genetic polymorphisms and expression properties

Research Project

Project/Area Number	21592543
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	Tsurumi University
Principal Investigator	OHSHIMA Tomoko 鶴見大学, 歯学部, 准教授 (50233101)
Co-Investigator(Kenkyū-buntansha)	KAMIYA Yoko 鶴見大学, 歯学部, 非常勤講師 (10460213)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	遺伝子発現 / 遺伝子多型 / 癌細胞特性 / 口腔扁平上皮癌 / バイオインフォマティクス / バイオイテンフォマティクス
Research Abstract	In order to understand the relationship between OSCC properties and gene mutation and to establish a standard for selection of therapy, the variety of gene expression and polymorphism and individual OSCC cell properties was analyzed. This study was conducted with the approval of Tsurumi University ethical review board. Informed consent was obtained from all of patients prior to this study. We performed SNP analysis to determine the gene polymorphism, DNA microarray analysis and proteome analysis. The common candidate in all analysis was not found but there is potential in combinations of plural candidates.