| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
To further evaluate the multipotency of dental pulp cells, and to investigate miRNA regulation of differentiation of these cells, we examined their in vitro differentiation into an endocrine cell lineage. After induction, insulin-producing cells were detected. Based on expression profiles by microRNA arrays, we identified targets, including molecules crucial for the differentiation into pancreatic beta cells. Thus, dental pulp cells have the potential to differentiate into an endocrine cell lineage by the regulation of miRNA following in vitro induction.
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