Effect of nitric oxide on mechanism of hematogenous metastasis and analysis of prevention of metastasis in adenoid cystic carcinoma
| Project/Area Number |
21592549
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
URADE Masahiro 兵庫医科大学, 医学部, 教授 (70104883)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 腺様嚢胞癌 / 転移 / 一酸化窒素合成酵素 / CXCR4 |
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| Research Abstract |
To elucidate effect of nitric oxide on mechanism of hematogenous metastasis and analysis of prevention of metastasis in adenoid cystic carcinoma, efficacy of single agent or combination chemotherapy of NOS inhibitor and CXCR4 antagonist was examined using xenograft mouse models of human adenoid cystic carcinoma. Treatment with iNOS inhibitor and combined therapy induced apoptosis and significant inhibitory effect for tumor-induced angiogenesis and proliferation of ACCIM. Blocking CXCR4 and iNOS inhibited lung metastasis of adenoid cystic carcinoma, suggesting that CXCR4 and iNOS may become molecular targets to inhibit tumor progression.
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Report
(4 results)
Research Products
(8 results)
