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An experimental study for development of real time diagnosis system for oral cancer treatment using nanobubbles and ultrasound

Research Project

Project/Area Number 21592550
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTohoku University

Principal Investigator

MORIKAWA Hidehiro  東北大学, 大学院・歯学研究科, 助教 (60302155)

Co-Investigator(Renkei-kenkyūsha) MORI Shiro  東北大学, 病院, 講師 (80230069)
KODAMA Tetsuya  東北大学, 大学院・医工学研究科, 教授 (40271986)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords口腔癌 / ナノバブル / 超音波 / 術中迅速診断 / リアルタイム
Research Abstract

The aim of the present study is to develop a real time imaging diagnosis system for oral cancer using nanobubbles and high-frequency ultrasound. As a result, the following problems were revealed, halation caused by the ultrasound contrast agent, blurring of the image caused by arterial pulsation, and imaging of the immature angiogenesis of the tumor. On the other hand, the diagnostic accuracy could be improved by analyzing the four-dimentional dynamics of nanobubbles in the blood flow. In this stu dy, to solve the problems, hardware and software of the high frequency-ultrasound imaging system were improved

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (26 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (22 results)

  • [Journal Article] Evaluation of transfection efficiency in skeletal muscle using nano/microbubbles and ultrasound2010

    • Author(s)
      Tetsuya Kodama, Atsuko Aoi, Yukiko Watabnabe, Sachiko Horie, Mizuho Kodama, Li Li, Rui Chen, Noriyoshi Teramoto, Hidehiro Morikawa, Shiro Mori, Manabu Fukumoto
    • Journal Title

      Ultrasound Med Biol

      Pages: 1196-1196

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Volumetricand angiogenetic imaging system by usingnanobubbles and high-frequency ultrasound for evaluation of the antitumor effect by cisplatin. The 5th InternationalSymposium on Medical, bio-Electronics.2010

    • Author(s)
      Yagisita Y, Takata Y, Ohki K, Miyashita H, Morikawa H, Sakamoto M, Mori S, Kawamura H, Kodama T
    • Journal Title

      Book of Abstract

      Pages: 161-162

    • Related Report
      2011 Final Research Report
  • [Journal Article] Evaluation of transfection efficiency in skeletal muscle using nano/microbubbles and ultrasound. Ultrasound in Medicine and Biology2010

    • Author(s)
      Kodama T, et al.
    • Journal Title

      Ultrasound Med Biol

      Volume: 36 Pages: 1196-1205

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Volumetric and angiogenetic imaging system by using nanobubbles and high-frequency ultrasound for evaluation of the antitumor effect by cisplatin.2010

    • Author(s)
      Yagishita Y, et al.
    • Journal Title

      The 5th International Symposium on Medical, Bio- and Nano-Electronics. Book of Abstract.

      Pages: 161-162

    • Related Report
      2009 Annual Research Report
  • [Presentation] 頭頸部癌所属リンパ節転移の診断・治療に向けたリンパ節腫大マウスを用いたリンパ節転移モデルの開発2011

    • Author(s)
      李麗, 森士朗, 柳下陽子, サックスニコラ, 堀江佐知子, 渡邊夕紀子, 高地崇, 李深偉, 宮下仁, 森川秀広, 阪本真弥, 小玉哲也
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Longitudinal three-dimentional noninvasive imaging analysis and quantification of ant-tumor effects of TNF-alpha gene for small tumor2010

    • Author(s)
      Sachiko Horie, Yukiko Watanabe, Yoko Yagishita, Nicolas Sax, Rui Chen, Li Li, Takanori Kojima, Hidehiro Morikawa, Maya Sakamoto, Masao Ono, Shiro Mori, Tetsuya Kodama
    • Organizer
      2010 World Molecular Imaging Congress.(Oral Presentation : 0717A)
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-09-08
    • Related Report
      2011 Final Research Report
  • [Presentation] ナノバブルと高周波超音波による腫瘍血管構築とVEGFの発現に関する分子学的検討2010

    • Author(s)
      宮下仁, 森士朗, 柳下陽子, 高田陽子, 大木宏介, 川村仁, 森川秀広, 小玉哲也
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 口腔癌早期診断のためのナノバブルと高周波超音波による腫瘍血管構築画像の病理学的評価2010

    • Author(s)
      柳下陽子, 森士朗, 高田陽子, 大木宏介, 宮下仁, 森川秀広, 川村仁, 小玉哲也
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ナノバブルと高周波超音波を用いた腫瘍血管構築法の開発2010

    • Author(s)
      柳下陽子, 森士朗, 李麗, 渡邊夕紀子, 堀江佐知子, 陳鋭, 高田陽子, 川村仁, 森川秀広, 小玉哲也
    • Organizer
      第26回日本DDS学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 口腔癌早期診断のためのナノバブルと高周波超音波を用いた画像診断法に関する組織学的検討2010

    • Author(s)
      柳下陽子, 森士朗, 李麗, 渡邊夕紀子, 堀江佐知子, 冨田典子, 陳鋭, 高田陽子, 大木宏介, 宮下仁, 小玉瑞穂, 川村仁, 森川秀広, 小玉哲也
    • Organizer
      第34回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Volumetric and angiogenetic imaging system by using nanobubbles and high-frequency ultrasound for evaluation of the antitumor effect by cisplatin2010

    • Author(s)
      Yagishita Y, Takata Y, Ohki K, Miyashita H, Morikawa H, Sakamoto M, Mori S, Kawamura H , Kodama T
    • Organizer
      The 5th International Symposium on Medical, Bio-and Nano-Electronics
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Longitudinal three-dimentional noninvasive imaging analysis and quantification of ant-tumor effects of TNF-alpha gene for smalltumor2010

    • Author(s)
      Sachiko Horie, et al.
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] Volumetric and angiogenetic imaging system by using nanobubbles and high-frequency ultrasound for evaluation of the antitumor effect by cisplatin.2010

    • Author(s)
      Yagishita Y, et al.
    • Organizer
      The 5th International Symposium on Medical, Bio- and Nano-Electronics
    • Place of Presentation
      Sendai, Japan.
    • Related Report
      2009 Annual Research Report
  • [Presentation] ナノバブルと超音波を用いた高周波超音波画像診断装置による微小転移検出に関する検討2009

    • Author(s)
      大木宏介、大木宏介、森士朗、士朗、高田陽子、宮下高田陽子、宮下高田陽子、宮下高田陽子、宮下高田陽子、宮下仁、川村仁、森川秀広、小玉哲也
    • Organizer
      第54回(社)日本口腔外科学会総会
    • Place of Presentation
      日, 札幌
    • Year and Date
      2009-10-11
    • Related Report
      2011 Final Research Report
  • [Presentation] ナノバブルと高周波超音波画像診断装置の遠隔地口腔診断への応用2009

    • Author(s)
      森士朗、高田陽子、大木宏介、宮下仁、川村仁、森川秀広、小玉哲也
    • Organizer
      第54回(社)日本口腔外科学会総会
    • Place of Presentation
      日, 札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔癌治療のためのナノバブルと超音波を用いた抗腫瘍効果増強法に関する検討2009

    • Author(s)
      宮下仁、森士朗、高田陽子、大木宏介、川村仁、森川秀広、小玉哲也
    • Organizer
      第54回(社)日本口腔外科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] ナノバブルと超音波を用いた口腔癌画像診断システムの診断精度に関する研究2009

    • Author(s)
      大木宏介、森士朗、李麗、堀江佐知子、渡邉夕紀子、宮下仁、川村仁、森川秀広、小玉哲也
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      日, 札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] ナノバブルと超音波を用いた抗腫瘍分子導入システムによる抗腫瘍効果に関する研究2009

    • Author(s)
      宮下仁、森士朗、李麗、堀江佐知子、渡邉夕紀子、大木宏介、川村仁、森川秀広、小玉哲也
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      日, 札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] ナノバブルと超音波を用いた口腔癌リアルタイム画像診断システムの開発に向けての検討2009

    • Author(s)
      森士朗、李麗、堀江佐知子、渡邉夕紀子、大木宏介、宮下仁、川村仁、森川秀広、小玉哲也
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      日, 札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] ナノバブルと超音波を用いた口腔癌リアルタイム画像診断システムの開発に向けての検討2009

    • Author(s)
      森士朗, 他
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] ナノバブルと超音波を用いた抗腫瘍分子導入システムによる抗腫瘍効果に関する検討2009

    • Author(s)
      宮下仁, 他
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] ナノバブルと超音波を用いた口腔癌画像診断システムの診断精度に関する検討2009

    • Author(s)
      大木宏介, 他
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] ナノバブルと超音波を用いた口腔癌診断システムの遠隔地医療への応用2009

    • Author(s)
      森士朗, 他
    • Organizer
      第35回(社)日本口腔外科学会北日本地方会
    • Place of Presentation
      旭川
    • Related Report
      2009 Annual Research Report
  • [Presentation] 口腔癌治療のためのナノバブルと超音波を用いた抗腫瘍効果増強法に関する検討2009

    • Author(s)
      宮下仁, 他
    • Organizer
      第54回(社)日本口腔外科学総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] ナノバブルと高周波超音波画像診断装置の遠隔地口腔診断への応用2009

    • Author(s)
      森士朗, 他
    • Organizer
      第54回(社)日本口腔外科学総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] ナノバブルと超音波を用いた高周波超音波画像診断装置による微小転移検出に関する検討2009

    • Author(s)
      大木宏介, 他
    • Organizer
      第54回(社)日本口腔外科学総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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