Exploitation of MICA gene polymorphism for development of personalized medicine in oral cancer patients

• Project/Area Number: 21592553
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: TANI Ryouji 広島大学, 病院, 助教 (10291486)
• Co-Investigator(Kenkyū-buntansha): OKAMOTO Tetsuji 広島大学, 医歯薬学総合研究科, 教授 (00169153) ; TORATANI Shigeaki 広島大学, 病院, 講師 (90172220)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: MICA gene polymorphism / oral cancer / soluble MICA / personalized medicine / MICA / sMICA / NK細胞 / 口腔癌 / 蛋白分解酵素

Research Abstract

The soluble MICA(_sMICA) in conditioned medium was measured by ELISA and we found the high level of_sMICA in KO cells. We have purified sMICA produced by KO cells.

Research Products

• [Journal Article] Furue MK. Growth factor-defined culture medium for human mesenchymal stem cells (2011)
  • Author(s): Mimura S, Kimura N, Hirata M, Tateyama D, Hayashida M, Umezawa A, Kohara A, Nikawa H, Okamoto T
  • Journal Title: Int J Dev Biol
  • Peer Reviewed
• [Journal Article] FGFR1abrogates inhibitory effect of androgen receptor concurrent with induction of androgen-receptor variants in androgen receptor-negative prostate tumor epithelial cells (2011)
  • Author(s): Kobayashi M, Huang Y, Jin C, Luo Y, Okamoto T, Wang F, McKeehan WL.
  • Journal Title: Prostate Volume: 71 Issue: 15 Pages: 1691-1700
  • DOI: 10.1002/pros.21386
  • Peer Reviewed
• [Journal Article] Growth factor-defined culture medium for human mesenchymal stem cells (2011)
  • Author(s): Mimura S
  • Journal Title: Int J Dev Biol Volume: 55(2) Pages: 181-187
  • Peer Reviewed
• [Journal Article] Central giant cell granuloma of mandible : presentation of a rare case with prominent Osteoblastic differentiation mimicking osteosarcoma (2010)
  • Author(s): Deraz EM, Ogawa I, Miyauchi M, Kudo Y, Nakamoto T, Tani R, Takata T
  • Journal Title: Oral Med Patho Volume: 14 Pages: 117-120
  • NAID: 130004509531
  • Peer Reviewed
• [Journal Article] Binding of APC and disheveled mediated Wnt5a-regulated focal adhesion dynamics in migrating cells (2010)
  • Author(s): Matsumoto S, Fumoto K, Okamoto T, Kaibuchi K, Kikuchi A.
  • Journal Title: EMBO J Volume: 29(7) Pages: 1192-204
  • Peer Reviewed
• [Journal Article] Tissue Culture : theunlimited potential (2010)
  • Author(s): Sato GH, Sato JD, Okamoto T, McKeehanWL, Barnes DW
  • Journal Title: In Vitro Cell DevBiol Anim Volume: 46(7) Pages: 590-4
  • Peer Reviewed
• [Journal Article] Advantages and difficulties inculturing human pluripotent stem cells in growth factor-defined serum-free medium (2010)
  • Author(s): Furue MK, Na J, Okamoto T, Sato JD. etal
  • Journal Title: In Vitro Cell Dev Biol Anim Volume: 46(7) Pages: 573-6
  • Peer Reviewed
• [Presentation] Developmental Signailing Disorders in Craniofacial Anomalies and Cancers (2009)
  • Author(s): Okamoto T
  • Organizer: Annual Meeting of Association for Denal sciences of the Republic of China, in Kaohsiung
  • Year and Date: 2009-11-13
• [Presentation] 機能性食品ケフィアの放射線化学療法による副作用の予防効果の検討 (2009)
  • Author(s): 谷亮治、虎谷茂昭, 岡本哲治
  • Organizer: 第63回日本口腔科学会学術集会
  • Place of Presentation: 浜松市
  • Year and Date: 2009-04-17
• [Presentation] 口腔扁平上皮癌におけるMICAおよび腫瘍内浸潤免疫細胞の細胞動態とその臨床的意義 (2009)
  • Author(s): 竹末奈七子
  • Organizer: 日本口腔科学会総会
  • Place of Presentation: アクトシティー浜松 (静岡県)
  • Year and Date: 2009-04-16
• [Patent(Industrial Property Rights)] BASAL MEDIUM FOR ES CELL CULTURING (2010)
  • Inventor(s): Okamoto T, Ashasima, M, Furue M
  • Industrial Property Rights Holder: Okamoto T, Ashasima, M
  • Acquisition Date: 2010-04-28
  • Overseas