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Analysis of cell motility system with EMT in tumor invasion and metastasis of oral cancer

Research Project

Project/Area Number 21592554
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionHiroshima University

Principal Investigator

SHIMASUE Hiroshi  広島大学, 病院, 助教 (40335683)

Co-Investigator(Kenkyū-buntansha) KAMATA Nobuyuki  広島大学, 大学院・医歯薬学総合研究科, 教授 (70242211)
HIGASHIKAWA Koichiro  広島大学, 病院, 講師 (80363084)
宮内 美和  広島大学, 病院, 講師 (10325201)
Co-Investigator(Renkei-kenkyūsha) SHIGEISHI Hideo  広島大学, 大学院・医歯薬学総合研究科, 助教 (90397943)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords口腔癌 / 上皮間葉移行 / 癌の浸潤・転移 / 細胞運動能制御 / Rho / 上皮・間葉移行 / 細胞運動制御 / 細胞運動制
Research Abstract

Snail, a transcription factor and EMT inducer, enable squamous cell carcinoma(SCC) cells to acquire high-invasiveness. Cyr61 is a humoral factor which known to be a angiogenesis factor and a target of which its transcription increases by Snail. Forced expression of Cyr61 in SCC cells directed their high-invasiveness and stimulation of recombinant Cyr61 gained their motility through activation of Rho. These data indicates that both of autocrine and paracrine Cyr61 offers crucial roles for the establishment of local invasion of SCC.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results)

  • [Journal Article] PGE(2) targets squamous cell carcinomacell with the activated epidermal growthfactor receptor family for survival against5-fluorouracil through NR4A2 induction2011

    • Author(s)
      Shigeishi H, Higashikawa K, Hatano H, Okui G, Tanaka F, Tran TT, Rizqiawan A, Ono S, Tobiume K, Kamata N
    • Journal Title

      CancerLett

      Volume: 307(2) Pages: 227-36

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphangiogenesis andmetastasis : Role of tumor-inducedlymphatic vessel activation inextramammary Paget' s disease2009

    • Author(s)
      Hirakawa S, Detmar M, Kerjaschki D, Nagamatsu S, Matsuo K, Tanemura A, Kamata N, Higashikawa K, Okazaki H, Kameda K, Nishida-Fukuda H, Mori H, Hanakawa Y, Sayama K, Shirakata Y, Tohyama M, Tokumaru S, Katayama I, Hashimoto K
    • Journal Title

      Am JPathol

      Volume: 175(5) Pages: 2235-48

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of the receptorfor hyaluronan-mediated motility, correlates with expression ofmicrotubule-associated protein in humanoral squamous cell carcinomas2009

    • Author(s)
      Shigeishi H, Fujimoto S, Hiraoka M, Ono S, Taki M, Ohta K, Higashikawa K, Kamata N
    • Journal Title

      Int J Oncol

      Volume: 34(6) Pages: 1565-1571

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] DeltaNp63alpha-dependent expression ofId-3 distinctively suppresses theinvasiveness of human squamous cellcarcinoma2009

    • Author(s)
      Higashikawa K, Yoneda S, Tobiume K, Saitoh M, Taki M, Mitani Y, Shigeishi H, Ono S, Kamata N
    • Journal Title

      Int J Cancer

      Volume: 124(12) Pages: 2837-2844

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 口腔癌の浸潤能診断(シンポジウム「癌細胞の浸潤・転移」2011

    • Author(s)
      東川晃一郎
    • Organizer
      第65回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2011-04-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌細胞の高度浸潤能獲得におけるCyr61の役割2010

    • Author(s)
      田中扶美
    • Organizer
      第64回日本口腔科学会学術集会・学術総会
    • Place of Presentation
      札幌
    • Related Report
      2010 Annual Research Report
  • [Presentation] Paracrine PGE2 targets epiregulin-overexpressing squamous cell carcinoma for resistance to anti-5-FU-induced apoptosis2010

    • Author(s)
      東川晃一郎
    • Organizer
      第69回日本癌学会・学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Snail target gene product Cyr61 regulates the invasiveness of squamous cell carcinoma2010

    • Author(s)
      東川晃一郎
    • Organizer
      第69回日本癌学会・学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌の抗癌剤耐性獲得機構における微小環境因子の関与2010

    • Author(s)
      東川晃一郎
    • Organizer
      第55回(社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌細胞の高度浸潤能獲得におけるCyr61の役割2010

    • Author(s)
      田中扶美
    • Organizer
      第55回(社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌における高度浸潤能獲得機構の解析2009

    • Author(s)
      田中扶美, 他
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Snailによる転写調節とEMTの誘導(シンポジウム「Epithelial MesennchymalTransitionと腫瘍の転移・浸潤」2009

    • Author(s)
      鎌田伸之, 東川晃一郎(講演者), 飛梅圭
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] A Snail-induced secretory protein associated with the invasiveness of squamous cell carcinoma2009

    • Author(s)
      田中扶美, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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