Chemoprevention for oral cancer targeting at microRNA
| Project/Area Number |
21592561
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUNIYASU Hiroki 奈良県立医科大学, 医学部, 教授 (00253055)
KIRITA Tadaaki 奈良県立医科大学, 医学部, 教授 (70201465)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | マイクロRNA / 口腔癌 / 化学予防 / ラット |
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| Research Abstract |
We investigated the expression of microRNA(miRNA) has-miR29b-1 which is located on chromosome 7q32 and is considered to be related to the invasion and metastasis of oral cancer and the expression of c-Met as the target gene downregulated by has-miR29b-1 which is located in chromosome 7q31, in oral squamous cell carcinoma(OSCC) surgical specimens and cell lines. Then, correlation of these with clinical markers and phenotype of epithelial-mesenchymal transition was investigated.
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Report
(4 results)
Research Products
(30 results)
