| Project/Area Number |
21592567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUNAHASHI Makoto 北海道大学, 大学院・歯学研究科, 教授 (80221555)
|
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| Co-Investigator(Renkei-kenkyūsha) |
KAMEKURA Nobuhito 北海道大学, 北海道大学病院, 講師 (80214550)
FUKUSHIMA Kazuaki 北海道大学, 大学院・歯学研究科, 教授 (00002361)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 歯科麻酔学 / 全身麻酔 / 悪心嘔吐 / c-Fos / 延髄最後野 / 悪心・嘔吐 / 低血圧 / 異食行動 / 術後悪心・嘔吐 |
|---|
| Research Abstract |
Postoperative nausea and vomiting is one of the most common complications, but its mechanism is unknown. In the present study, we studied the c-Fos expression in the area postrema for the purpose of investigating whether intraoperative hypotension causes postoperative nausea and vomiting. Hypotension significantly increased c-Fos expression in the area postrema of the rats received isoflurane or propofol anesthesia. Although we could not confirm the evidence by behavioral experiments, it is possible that nervous excitement in the area postrema by intraoperative hypotension causes nausea and vomiting.
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