| Project/Area Number |
21592568
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MATSUI Keiko 東北大学, 大学院・歯学研究科, 助教 (00302159)
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| Co-Investigator(Kenkyū-buntansha) |
KAMAKURA Sinji 東北大学, 大学院・医工学研究科, 教授 (80224640)
ECHIGO Seishi 東北大学, 大学院・歯学研究科, 教授 (70005114)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リン酸カルシウム系生体材料 / 骨再生 / ビーグル幼犬 / 未萌出永久歯 / リン酸オクタカルシウム・コラーゲン複合体(OCP/Col) / 顎裂部自家骨移植 / リン酸オクタカルシウム(OCP) / OCP/Col / 後続永久歯萌出 / リン酸オクタカルシウム / ビーグル犬 / 幼犬 |
|---|
| Research Abstract |
The purpose of this study was to investigate whether Octacalcium phosphate (OCP)collagen composites (OCP/Col)could be applied to alveolar clefts with unerupted permanent teeth as an alternative to autogenous particulate cancellous bone grafts. In two-month-old beagle dogs, the lower deciduous second/third molar teeth were extracted and the tooth extraction sockets were filled with either OCP/Col or SS-tricalcium phosphate (SS-TCP). The permanent third/fourth premolars (P3/P4)erupted through all the OCP/Col-implanted sites, whereas P3 and P4 were completely impacted in some of the SS-TCP-implanted regions. These results suggest that OCP/Col may be clinically applicable as an alternative to autogenous bone graft.
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