| Project/Area Number |
21592572
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ASAUMI Junichi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (60184131)
YANAGI Yoshinobu 岡山大学, 岡山大学病院, 講師 (50284071)
HISATOMI Miki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60314704)
MATSUZAKI Hidenobu 岡山大学, 岡山大学病院, 助教 (70325124)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口腔癌 / リンパ節転移 / リンパ管 / dynamic CE-MRI / MRI / 免疫染色 / ｄｙｎａｍｉｃ ＣＥ―ＭＲＩ |
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| Research Abstract |
In recent years, it has become clear that the hyperplasia of ablood vessel and the hyperplasia of a lymph vessel have correlation in a cancer. Cancer cells are metastasized through a lymph vessel. Then, since dynamic CE-MRI can perform the diagnostic imaging reflecting the blood flow in a tumor, the hyperplasia of the lymph vessel in a cancer was evaluated by dynamic CE-MRI. Correlation positive in dynamic CE-MRI and the number of the blood vessels in a tumor on a pathology specimen was shown. Moreover, although positive correlation was shown also between the number of the blood vessels in a tumor on a pathology specimen and the number of lymph vessels, correlation was not shown between dynamic CE-MRI and the number of lymph vessels on a pathology specimen. However, the significant difference was shown between dynamic CE- MRI of the primary lesion with lymph-nodes metastasis group and with non- lymph-nodes metastasis group.
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