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Development of the melatonin treatment which aimed at shortening of the recovery period after operation related bone tissue.

Research Project

Project/Area Number 21592575
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTsurumi University

Principal Investigator

SATOMURA Kazuhito  鶴見大学, 歯学部, 教授 (80243715)

Co-Investigator(Kenkyū-buntansha) TATEHARA Seiko  鶴見大学, 歯学部, 助教 (90380089)
TOKUYAMA Reiko  鶴見大学, 歯学部, 助教 (20380090)
YAMAMOTO Hideo  鶴見大学, 歯学部, 講師 (10220493)
HATTORI Atsuhiko  東京医科歯科大学, 教養部, 教授 (70183910)
TACHIBANA Ryusuke  鶴見大学, 歯学部, 臨床助手 (80514926)
工藤 景子  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (70380029)
湯浅 哲也  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (70332822)
神谷 洋子  鶴見大学, 歯学部, 助教 (10460213)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords口腔外科学一般 / メラトニン / 骨関連手術 / 治癒期間短縮 / 骨組織再生 / 骨折治癒 / 歯の再生 / インプラント / メラトニン受容体 / 硬組織再生 / 歯の発生 / 唾液腺
Research Abstract

Melatonin, which is controlled by the light/dark cycle of the environment, promote growth and differentiation of osteoblasts. In this study, we elucidated that melatonin have the potential to promote the healing after bone fracture and osseointegration after dental implantation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(11 results)

All 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Expression and cellular localization of melatonin-synthesizing enzymes in rat and human salivary glands2011

    • Author(s)
      Masashi Shimozuma, Kazuhito Satomura, et al
    • Journal Title

      Histchemistry and Cell Biology

      Volume: 135 Pages: 389-396

    • Related Report
      2011 Final Research Report
  • [Journal Article] Possible involvement of melatonin in tooth development : expression of melatonin 1a receptor in human and mouse tooth ger2010

    • Author(s)
      Shuku Kumasaka, Kazuhito Satomura, et al
    • Journal Title

      Histochemistry and Cell Biology

      Volume: 133 Pages: 577-584

    • Related Report
      2011 Final Research Report
  • [Journal Article] Possible involvement of melatonin in tooth development : Expression of melatonin 1a receptor in human and mouse tooth germs.2010

    • Author(s)
      Kumasaka S, et al.
    • Journal Title

      Histochemistry and Cell Biology

      Volume: 133 Pages: 577-584

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of melatonin in tooth development : Expression of melatonin 1a receptor in human and mouse tooth germs.2010

    • Author(s)
      Kumasaka S, et al.
    • Journal Title

      Histochemistry and Cell Biology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and cellular localization of melatonin-synthesizing enzymes in rat and human salivary glands.

    • Author(s)
      Shimozuma M, et al.
    • Journal Title

      Histochemistry and Cell Biology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 唾液腺におけるメラトニン合成酵素の発現とその経時的変化2011

    • Author(s)
      下間雅史、里村一人, 他
    • Organizer
      第56回日本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 唾液腺におけるメラトニン合成酵素の発現とその経時的変化2011

    • Author(s)
      下間雅史、徳山麗子、里村一人, 他
    • Organizer
      第56回日本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 唾液腺におけるメラトニン合成酵素の発現とその局在2011

    • Author(s)
      下間雅史、里村一人, 他
    • Organizer
      第11会日本抗加齢医学会総会・学術大会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 唾液腺におけるメラトニン合成酵素の発現とその局在2011

    • Author(s)
      下間雅史、徳山麗子、里村一人, 他
    • Organizer
      第11回日本抗加齢医学会総会・学術大会
    • Place of Presentation
      京都(京都国際会議場)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] メラトニンと骨再生2009

    • Author(s)
      里村一人
    • Organizer
      第1回抗加齢内分泌研究会
    • Place of Presentation
      東京医科歯科大学(東京)
    • Year and Date
      2009-09-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯科からみた抗加齢内分泌研究2009

    • Author(s)
      里村一人
    • Organizer
      日本抗加齢医医学会講習会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2009-04-26
    • Related Report
      2009 Annual Research Report

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Published: 2009-03-31   Modified: 2016-04-21  

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