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Effects of intravenous sedation on higher brain function and development of new intravenous sedatives

Research Project

Project/Area Number 21592580
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTsurumi University (2010-2011)
Kyushu Dental College (2009)

Principal Investigator

KAWAHARA Hiroshi  鶴見大学, 歯学部, 教授 (10186124)

Co-Investigator(Kenkyū-buntansha) KAWAHARA Yukie  久留米大学, 医学部, 講師 (10279135)
HARANO Nozomu  九州歯科大学, 歯学部, 助教 (50423976)
仲西 修  九州歯科大学, 歯学部, 教授 (50137345)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歯科麻酔学 / ストレス / 抗不安薬 / 鎮静薬 / 静脈内鎮静法 / マイクロダイアリシス / 中枢神経系 / ラット / 鎮静 / 抗不安 / 脳科学 / マイクロダイアリシ / 情動 / 歯科治療 / デクスメデトミジン
Research Abstract

We studied effects of the acute stress on monoamine neural activity in the rat brain The actions of the anxiolytis and sedatives on the central nervous system have been studied by microdialysis. This approach has shown that anxiolytis and sedatives suppress the accentuation of the locus coeruleus-medial prefrontal cortex noradrenaline neural activity, the accentuation of the ventral tegmental area-nucleus accumbens dopamine neuron activity, and the accentuation of the raphe-amygdala serotonin neuron activity in the stress state.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (26 results)

All 2012 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (14 results) Book (4 results)

  • [Journal Article] Comparison of the depression-like behavior and serotonergic system between Wistar and Wistar-Kyoto rat strains2011

    • Author(s)
      Kawahara Y, Yamada M, Kaneko F, Furushima E, Dremencov E, Kawahara H, Nishi A
    • Journal Title

      Japanese Journal of Neuropsychopharamacology

      Volume: 31 Pages: 898-899

    • NAID

      10029094175

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the depression-like behavior and serotonergic system between Wistar and Wistar-Kyoto rat strains2011

    • Author(s)
      Yamada M, Kawahara Y, Kaneko F, Furushima E, Dremencov E, Kawahara H, Nishi A
    • Journal Title

      Japanese Journal of Neuropsychopharamacology

      Volume: 31 Pages: 89-90

    • NAID

      10029094175

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the serotonergic system and behavior between Wistar and Wistar-Kyoto rats2011

    • Author(s)
      Kawahara H
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 115 Pages: 252-252

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] グライドスコープによる経鼻気管挿管2010

    • Author(s)
      河原博
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 38 Pages: 35-38

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] エアウェイスコープによる経鼻挿管を行う際のイントロック先端位置に関する研究2010

    • Author(s)
      河原博
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 38 Pages: 187-192

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states2009

    • Author(s)
      Kawahara Y, Kawahara H, Kaneko F, Yamada M, Nishi Y, Tanaka E, Nishi A
    • Journal Title

      Neuroscience

      Volume: 161 Pages: 855-864

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripherally administered ghrelin induces bimodal effects on mesolimbic dopamine system depending on food-consumptive states2009

    • Author(s)
      Kawahara H
    • Journal Title

      Neuroscience 161

      Pages: 855-864

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] イントロック・先端部を喉頭蓋谷に位置させるエアウェイスコープ〓経鼻気管挿管の検討2009

    • Author(s)
      河原博
    • Journal Title

      日本歯科麻酔学会雑誌 37

      Pages: 172-175

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Peripherally administration ghrelin modulates the mesolimbic2dopaminesystem via distinct opioid pathways associated with reward value of food2012

    • Author(s)
      Kawahara Y, Kaneko F, YamadaM, Furushima Y, Kawahara H, Nishi A
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会議場,京都府
    • Related Report
      2011 Final Research Report
  • [Presentation] Compariosn of the dorsal raphe serotonergic circuitry in WKY and Wistar rat strains2012

    • Author(s)
      Yamada M, Kawahara Y, Kaneko F, Furushima E, Dremencov E, Kawahara H, Nishi A
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会議場,京都府
    • Related Report
      2011 Final Research Report
  • [Presentation] Peripherally administration ghrelin modulates the mesolimbic dopaminesystem via distinct opioid pathways associated with reward value of food2012

    • Author(s)
      Kawahara Y, Kaneko F, Yamada M, Furushima Y, Kawahara H, Nishi A
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会議場(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Compariosn of the dorsal raphe serotonergic circuitry in WKY and Wistar rat strains2012

    • Author(s)
      Yamada M, Kawahara Y, Kaneko F, Furushima E, Dremencov E, Kawahara H, Nishi A
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会議場(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Distinct opioid pathways mediate the effect of ghrelin on the mesolimbic dopamine system associated with food reward2011

    • Author(s)
      Kawahara Y, Kaneko F, YamadaM, Furushima Y, Dremencov E, Kawahara H, Nishi A
    • Organizer
      第22回マイクロダイアリシス研究会
    • Place of Presentation
      お茶の水女子大学,東京都
    • Year and Date
      2011-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Depression-like behavior in WKY rat strain was affected by repeated treatment of escitalopram : involvement of serotonin system in the prefrontal cortex2011

    • Author(s)
      Yamada M, Kawahara Y, Kaneko F, Furushima E, Dremencov E, Kawahara H, Nishi A
    • Organizer
      第22回マイクロダイアリシス研究会
    • Place of Presentation
      お茶の水女子大学,東京都
    • Year and Date
      2011-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Depression-like behavior in WKY rat strain was affected by repeated treatment of escitalopram : involvement of serotonin system in the prefrontal cortex2011

    • Author(s)
      Yamada M, Kawahara Y, Kaneko F, Furushima E, Dremencov E, Kawahara H, Nishi A
    • Organizer
      第22回マイクロダイアリシス研究会
    • Place of Presentation
      お茶の水女子大学(東京都)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Distinct opioid pathways mediate the effect of ghrelin on the mesolimbic dopamine system associated with food reward2011

    • Author(s)
      Kawahara Y, Kaneko F, Yamada M, Furushima Y, Dremencov E, Kawahara H, Nishi A
    • Organizer
      第22回マイクロダイアリシス研究会
    • Place of Presentation
      お茶の水女子大学(東京都)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dorsal raphe nucleus serotonin neurons in WKY rats demonstrates subresponsivity to an acute application of escitalopram : effect of repeated escitalopram treatment2011

    • Author(s)
      Yamada M, Kawahara Y, Kaneko F, Furushima E, Dremencov E, Kawahara H, Nishi A
    • Organizer
      2nd Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Grand Hilton Seoul Hotel, South Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Dorsal raphe nucleus serotonin neurons in WKY rats demonstrates subresponsivity to an acute application of escitalopram : effect of repeated escitalopram treatment2011

    • Author(s)
      Yamada M, Kawahara Y, Kaneko F, Furushima E, Dremencov E, Kawahara H, Nishi A
    • Organizer
      2nd Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Grand Hilton Seoul Hotel(大韓民国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Comparison of the depression-like behavior and serotonergic sysytem between Wistar and Wistar-Kyoto strains of rats2010

    • Author(s)
      Kawahara H
    • Organizer
      27th Collegium Internatinale Neuro-Psychopharmacologium
    • Place of Presentation
      Hong Kong International Conference Center, China
    • Year and Date
      2010-06-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparison of the depression-like behavior and serotonergic sysytem between Wistar and Wistar-Kyoto strains of rats2010

    • Author(s)
      Kawahara H
    • Organizer
      27th Collegium Internatinale Neuro-Psychopharmacologium
    • Place of Presentation
      HongKong
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Peripherally administered ghrelin induces bimodal effects on mesolimbic dopamine system depending on food-consumptive states2009

    • Author(s)
      Kawahara H
    • Organizer
      2009 International Symposium of Ghrelin
    • Place of Presentation
      Tokyo Forum Tokyo
    • Year and Date
      2009-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Peripherally administered ghrelin induces bimodal effects on mesolimbic dopamine system depending on food-consumptive states.2009

    • Author(s)
      Kawahara H
    • Organizer
      2009 International Symposium of Ghrelin
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Book] 歯科麻酔学第7版2011

    • Author(s)
      河原博, 他
    • Total Pages
      621
    • Publisher
      医歯薬出版
    • Related Report
      2011 Final Research Report
  • [Book] 歯科鎮静法ハンドブック2011

    • Author(s)
      河原博, 他
    • Total Pages
      62
    • Publisher
      永末書店
    • Related Report
      2011 Final Research Report
  • [Book] 歯科麻酔学第7版2011

    • Author(s)
      河原博
    • Total Pages
      621
    • Publisher
      医歯薬出版
    • Related Report
      2011 Annual Research Report
  • [Book] 歯科鎮静法ハンドブック2011

    • Author(s)
      河原博
    • Total Pages
      62
    • Publisher
      永末書店
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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