Effects of intravenous sedation on higher brain function and development of new intravenous sedatives
| Project/Area Number |
21592580
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University (2010-2011)
Kyushu Dental College (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Yukie 久留米大学, 医学部, 講師 (10279135)
HARANO Nozomu 九州歯科大学, 歯学部, 助教 (50423976)
仲西 修 九州歯科大学, 歯学部, 教授 (50137345)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯科麻酔学 / ストレス / 抗不安薬 / 鎮静薬 / 静脈内鎮静法 / マイクロダイアリシス / 中枢神経系 / ラット / 鎮静 / 抗不安 / 脳科学 / マイクロダイアリシ / 情動 / 歯科治療 / デクスメデトミジン |
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| Research Abstract |
We studied effects of the acute stress on monoamine neural activity in the rat brain The actions of the anxiolytis and sedatives on the central nervous system have been studied by microdialysis. This approach has shown that anxiolytis and sedatives suppress the accentuation of the locus coeruleus-medial prefrontal cortex noradrenaline neural activity, the accentuation of the ventral tegmental area-nucleus accumbens dopamine neuron activity, and the accentuation of the raphe-amygdala serotonin neuron activity in the stress state.
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Report
(4 results)
Research Products
(26 results)
