Effect of acute pain stimulation for mouth floor on myocardium
| Project/Area Number |
21592583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMAE Masami 大阪歯科大学, 歯学部, 講師 (20298821)
KOTANI Junichiro 大阪歯科大学, 歯学部, 教授 (40109327)
DOMAE Naochika 大阪歯科大学, 歯学部, 名誉教授 (60115889)
KANEDA Kazuhiro 大阪歯科大学, 歯学部, 研究員 (90533886)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口腔急性疼痛 / 心筋虚血再灌流障害 / リモートプレコンディショニング |
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| Research Abstract |
We investigated the effect of acute pain stimulation for mouth floor on expression of extracellular signal-regulated kinase(ERK) in the spinal nucleus of trigeminal nerve using immunohistochemical staining. Electrical noxious stimulation for mouth floor for 2 min increased spectral edge frequency 95 on electroencephalography accompanied by increased phosphorylation of ERK in the spinal nucleus of trigeminal nerve. This model can be applied to evaluate the effect of acute pain stimulation for mouth floor on cardioprorection by remote preconditioning in the future.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Acute memory phase of sevoflurane preconditioning is associated with sustained translocation of protein kinase C-alpha and epsilon, but not delta, in isolated guinea pig hearts2009
Author(s)
OKUSA C, MIYAMAE M, SUGIOKA S, KANEDA K, INAMIRA Y, ONISHI A, DOMAE N, KOTANI J, FIGUEREDO VM
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Journal Title
Eur J Anaesthesiol
Volume: 26
Pages: 582-588
Related Report
Peer Reviewed
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[Presentation] Cardioprotection by regular ethanol consumption is mediated through the bradykinin B2 receptor through increased nitric oxide production2010
Author(s)
KANEDA K, MIYAMAE M, SUGIOKA S, OKUSA C, INAMURA Y, ONISHI A, SHIOMI M, OKAMURA S, DOMAE N, FIGUEREDO VM, KOTANI J
Organizer
American Heart Assiciation Scientific Sessions 2010
Place of Presentation
Chikago, USA
Year and Date
2010-11-17
Related Report
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[Presentation] ジピリダモール,セボフルラン, NO供与薬による心筋プレコンディショニングの比較および相互作用2010
Author(s)
大草知佳, 宮前雅見, 杉岡伸悟, 金田一弘, 稲村吉高, 大西杏奈, 塩見真由美, 岡村静, 堂前尚親, 小谷順一郎
Organizer
第38回日本歯科麻酔学会総会・学術集会
Place of Presentation
横須賀芸術劇場(横須賀市)
Year and Date
2010-10-09
Related Report
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[Presentation] モルモット口腔内侵害刺激における脳波変化と三叉神経脊髄路核におけるpERKの発現2010
Author(s)
杉岡伸悟, 宮前雅見, 松田佳子, 讃岐拓郎, 金田一弘, 大草知佳, 稲村吉高, 大西杏奈, 塩見真由美, 岡村静, 堂前尚親, 小谷順一郎
Organizer
第38回日本歯科麻酔学会総会・学術集会
Place of Presentation
横須賀芸術劇場(横須賀市)
Year and Date
2010-10-08
Related Report
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