An analysis of the role of FGF receptors in early mandibular patterning by using RNA interference
Project/Area Number |
21592587
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthodontic/Pediatric dentistry
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Research Institution | Kyushu University (2010-2011) Tohoku University (2009) |
Principal Investigator |
TERAO Fumie 九州大学, 大学院・歯学研究院, 助教 (10510018)
|
Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Ichiro 九州大学, 大学院・歯学研究院, 教授 (70241643)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | FGF / 受容体 / 下顎隆起 / 器官形成 / RNA / 干渉 / FGF受容体 / RNA干渉 / 器官培養 |
Research Abstract |
We investigated the gene expression pattern of FGFR genes in early mandibular development in rats. In the mandibular cell micromass culture, the activation of FGF-FGFR signal by recombinant FGF treatment enhanced endogenous ERK(extracellular signal-regulated kinase) phosphorylation. The transfection of induced by the electroporation of an Fgfr2c short hairpin RNA(shRNA) vector altered the shape of Meckel' s cartilage. These results indicate that FGFR plays an important role during early mandibular morphogenesis.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Suzuki O Molecular Mechanisms of Mechanical Stress Response during Chondrogenesis J Biochem Sci Eng.2009
Author(s)
Takahashi I, Masuda T, Kohsaka K, Terao F, Anada T, Sasano Y, Takano-YamamotoTakahashi I, Masuda T, Kohsaka K, Terao F, Anada T, Sasano Y, Takano-YamamotoTakahashi I, Masuda T, Kohsaka K, Terao F, Anada T, Sasano Y, Takano-Yamamoto T.
Volume
4
Pages
307-317
Related Report
Peer Reviewed
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