| Project/Area Number |
21592604
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Motohiro 長崎大学, 医歯薬学総合研究科, 助教 (90420629)
芝崎 龍典 長崎大学, 医歯薬学総合研究科, 助教 (70399757)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯根吸収 / ラット / 歯の移動 / コイルスプリング / アポトーシス / 薬 / アポトーシフ |
|---|
| Research Abstract |
In order to evaluate the effect of apoptosis inhibitors on orthodontically induced root resorption, an orthodontic appliance was applied on the rats. Several apoptosis inhibitors such as lithiun cloride and selegiline hydrocloride were administrated to the rats and the root resorption was measured. The inhibitory effect of any apoptosis inhibitor on root resorption was not observed. However, in the course of this study, root resorption in the ovalectomized rats was found to be increased, on the other hand, root resorption of the fluoride-treated rats was found to be inhibited.
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