| Project/Area Number |
21592606
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAURA Hideki 東北大学, 病院, 講師 (60295087)
YOSHIDA Noriaki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (40230750)
|
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIMURA Yuji 長崎大学, 大学院・医歯薬学総合研究科, 助教 (70448504)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
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| Keywords | SHIP / TNF-α / 破骨細胞 / 矯正歯科 / 矯正学的歯の移動 |
|---|
| Research Abstract |
SH2-containing inositol-5'-phosphatase(SHIP), which is related to immunoreaction, has been reported to negatively regulate the proliferation of osteoclast precursors induced by macrophage colony-stimulating factor(M-CSF) and ligand for receptor activator of nuclear factor kappa B(RANKL). In this study, we investigated the effects of SHIP on TNF-α-induced osteoclastogenesis. Bone marrow cells from SHIP+/+ and SHIP-/-mice were cultured with M-CSF and TNF-α. The number of TRAP-positive cells was significantly increased in SHIP-/-cells compared with SHIP+/+ cells. These results suggest that SHIP may negatively regulate the proliferation of osteoclast precursors.
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