Analysis of SHIP related to osteoclastogenesis

• Project/Area Number: 21592606
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Nagasaki University
• Principal Investigator: YOSHIMATSU Masako 長崎大学, 病院, 助教 (20420630)
• Co-Investigator(Kenkyū-buntansha): KITAURA Hideki 東北大学, 病院, 講師 (60295087) ; YOSHIDA Noriaki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (40230750)
• Co-Investigator(Renkei-kenkyūsha): FUJIMURA Yuji 長崎大学, 大学院・医歯薬学総合研究科, 助教 (70448504)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: SHIP / TNF-α / 破骨細胞 / 矯正歯科 / 矯正学的歯の移動

Research Abstract

SH2-containing inositol-5'-phosphatase(SHIP), which is related to immunoreaction, has been reported to negatively regulate the proliferation of osteoclast precursors induced by macrophage colony-stimulating factor(M-CSF) and ligand for receptor activator of nuclear factor kappa B(RANKL). In this study, we investigated the effects of SHIP on TNF-α-induced osteoclastogenesis. Bone marrow cells from SHIP+/+ and SHIP-/-mice were cultured with M-CSF and TNF-α. The number of TRAP-positive cells was significantly increased in SHIP-/-cells compared with SHIP+/+ cells. These results suggest that SHIP may negatively regulate the proliferation of osteoclast precursors.

Research Products

• [Journal Article] Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice (2012)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N
  • Journal Title: Arch Oral Biol Volume: 57(1) Pages: 36-43
• [Journal Article] Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo (2012)
  • Author(s): Kimura K, Kitaura H, Fujii T, Hakami ZW, Takano-Yamamoto T
  • Journal Title: FEMS Immunol Med Microbio Volume: 64(2) Pages: 219-227
• [Journal Article] Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice (2012)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimuar Y, Kohara H, Morita Y, Eguchi T, Yoshida N
  • Journal Title: Arch Oral Biol Volume: 57 Issue: 1 Pages: 36-43
  • DOI: 10.1016/j.archoralbio.2011.07.006
  • Peer Reviewed
• [Journal Article] Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo (2012)
  • Author(s): Kimura K, Kitaura H, Fujii T, Hakami ZW, Takano-Yamamoto T
  • Journal Title: FEMS Immunol Med Microbiol Volume: 64 Issue: 2 Pages: 219-227
  • DOI: 10.1111/j.1574-695x.2011.00888.x
  • Peer Reviewed
• [Journal Article] IL-12-and IL-18-mediated, nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis of bone marrow cells (2011)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Masuyama R, Yoshida N, Takano-Yamamoto T
  • Journal Title: Calcif Tissue Int Volume: 89(1) Pages: 65-73
• [Journal Article] IFN-γdirectly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/ Fas ligand interactions (2011)
  • Author(s): Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, Masuyama R, Yoshida N
  • Journal Title: Immunol Lett Volume: 30(137) Pages: 53-61
• [Journal Article] Tooth movement and root resorption ; The effect of ovariectomy on orthodontic force application in rats. (2011)
  • Author(s): Sirisoontorn I, Hotokezaka H, Hashimoto M, Gonzales C, Luppanapornlarp S, Darendeliler MA, Yoshida N
  • Journal Title: Angle Orthod Volume: 81(4) Pages: 570-577
  • NAID: 120006985636
• [Journal Article] Effects of fluoride intake on orthodontic tooth movement and orthodontically induced root resorption (2011)
  • Author(s): Gonzales C, Hotokezaka H, Karadeniz EI, Miyazaki T, Kobayashi E, Darendeliler MA, Yoshida N
  • Journal Title: Am J Orthod Dentofacial Orthop Volume: 139(2) Pages: 196-205
• [Journal Article] IL-12- and IL-18-mediated, nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis of bone marrow cells (2011)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Masuyama R, Yoshida N, Takano-Yamamoto T
  • Journal Title: Calcif Tissue Int Volume: 89 Issue: 1 Pages: 65-73
  • DOI: 10.1007/s00223-011-9494-0
  • Peer Reviewed
• [Journal Article] IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions (2011)
  • Author(s): Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, Masuyama R, Yoshida N
  • Journal Title: Immunol Lett Volume: 30 Issue: 1-2 Pages: 53-61
  • DOI: 10.1016/j.imlet.2011.02.017
  • Peer Reviewed
• [Journal Article] Tooth movement and root resorption ; The effect of ovariectomy on orthodontic force application in rats (2011)
  • Author(s): Sirisoontom I, Hotokezaka H, Hashimoto M, Gonzales C, Luppanapornlarp S, Darendeliler MA, Yoshida N
  • Journal Title: Angle Orthod Volume: 81 Issue: 3 Pages: 570-577
  • DOI: 10.2319/052007-240.1
  • NAID: 120006985636
  • Peer Reviewed
• [Journal Article] IL-18 inhibits TNF-alpha-induced osteoclastogenesis possibly via a T cell-independent mechanism in synergy with IL-12 in vivo (2010)
  • Author(s): Morita Y, Kitaura H, Yoshimatsu M, Fujimura Y, Kohara H, Eguchi T, Yoshida N
  • Journal Title: Calcif Tissue Int Volume: 86(3) Pages: 242-248
• [Journal Article] Repair of root resorption 2 to 16 weeks after the application of continuous forces on maxillary first molars in rats : a 2-and 3-dimensional quantitative evaluation (2010)
  • Author(s): Gonzales C, Hotokezaka H, Darendeliler MA, Yoshida N
  • Journal Title: Am J Orthod Dentofacial Orthop Volume: 137(4) Pages: 477-485
  • NAID: 120006984562
• [Journal Article] IL-18 inhibits TNF-alpha-induced osteoclagtogenesis possibly via a T cell-independent mechanism in synergy with IL-12 in vivo. (2010)
  • Author(s): Morita Y, et al
  • Journal Title: Calcif Tissue Int. Volume: 86 Pages: 242-248
  • Peer Reviewed
• [Journal Article] IL-12 inhibits TNF-alpha induced osteoclastogenesis via a T cell-independent mechanism in vivo (2009)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimura Y, Eguchi T, Kohara H, Morita Y, Yoshida N
  • Journal Title: Bone Volume: 45(5) Pages: 1010-1016
• [Journal Article] Influence of bisphosphonates on orthodontic tooth movement in mice (2009)
  • Author(s): Fujimura Y, Kitaura H, Yoshimatsu M, Eguchi T, Kohara H, Morita Y, Yoshida N
  • Journal Title: Eur J Orthod Volume: 31(6) Pages: 572-577
• [Journal Article] An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice (2009)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Eguchi T, Kohara H, Jang I, Morita Y, Yoshida N
  • Journal Title: Angle Orthod Volume: 79(5) Pages: 835-841
• [Journal Article] An in vivo 3D micro-CT evaluation of tooth movement after the application of different force magnitudes in rat molar (2009)
  • Author(s): Gonzales C, Hotokezaka H, Arai Y, Ninomiya T, Tominaga J, Jang I, Hotokezaka Y, Tanaka M, Yoshida N
  • Journal Title: Angle Orthod Volume: 79(4) Pages: 703-714
  • NAID: 120006985644
• [Journal Article] Effects of steroidal and nonsteoridal drugs on tooth movement and root resorption in the rat molar (2009)
  • Author(s): Gonzales C, Hotokezaka H, Matsuo KI, Shibazaki T, Yozgatian J, Darendeliler MA, Yoshida N
  • Journal Title: Angle Orthod Volume: 79(4) Pages: 715-726
• [Journal Article] Effect of celecoxib on emotional stress and pain-related behaviors evoked by experimental tooth movement in the rat (2009)
  • Author(s): Shibazaki T, Yozgatian JH, Zeredo JL, Gonzales C, Hotokezaka H, Koga Y, Yoshida N
  • Journal Title: Angle Orthod Volume: 79(6) Pages: 1169-1174
  • NAID: 120006985635
• [Presentation] Effects of IFN-γon tooth movement (2011)
  • Author(s): Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
  • Organizer: Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] IL-12-and IL-18-mediated nitric oxide induced apoptosis in TNF-α-mediated osteoclastogenesis (2011)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Yoshida N, Takano-Yamamoto T
  • Organizer: Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] Effects of SHIP on TNF-alpha-induced osteoclastogenesis (2011)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N
  • Organizer: Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] Effects of IFN-γ on tooth movement (2011)
  • Author(s): Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
  • Organizer: Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] IL-12- and IL-18-mediated nitric oxide induced apoptosis in TNF-α-mediated osteoclastogenesis (2011)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Yoshida N
  • Organizer: Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] 矯正学的歯の移動時の歯根吸収におけるIL-12の作用について (2010)
  • Author(s): 吉松昌子
  • Organizer: 日本矯正歯科学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-28
• [Presentation] 矯正学的歯の移動時におけるIL-12の作用について (2010)
  • Author(s): 吉松昌子、北浦英樹、藤村裕治、小原悠、森田幸子、江口俊子、吉田教明
  • Organizer: 第69回日本矯正歯科学会大会
  • Place of Presentation: 横浜
• [Presentation] 矯正学的歯の移動に対するIFN-γの発現およびその影響 (2010)
  • Author(s): 小原悠、北浦英樹、吉松昌子、藤村裕治、森田幸子、江口俊子、吉田教明
  • Organizer: 第69回日本矯正歯科学会大会
  • Place of Presentation: 横浜
• [Presentation] IL-18のTNF-α誘導破骨細胞形成抑制作用におけるT細胞の関与の検討 (2010)
  • Author(s): 森田幸子、北浦英樹、吉松昌子、藤村裕治、小原悠、江口俊子、吉田教明
  • Organizer: 第69回日本矯正歯科学会大会
  • Place of Presentation: 横浜
• [Presentation] 炎症性サイトカインであるTNF-αによる破骨細胞形成に対するTh1サイトカインの作用について (2009)
  • Author(s): 北浦英樹、山本照子
  • Organizer: 第6回東北大学バイオサイエンスシンポジウムおよび第14回学際ライフサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-16
• [Presentation] IL-12 inhibits TNF-αmediated osteoclastogenesis via a T cell-independent mechanism in vivo (2009)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Takano-Yamamoto T, Yoshida N
  • Organizer: Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Denver, USA
• [Presentation] IL-12-and IL-18-mediated nitric oxide induces apoptosis in TNF-α-induced osteoclastogenesis of bone marrow cells (2009)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Eguchi T, Yoshida N, Takano-Yamamoto T
  • Organizer: Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Denver, USA
• [Presentation] Effect of bisphosphonates on orthodontic tooth movement in mice (2009)
  • Author(s): Fujimura Y, Kitaura H, Yoshimatsu M, Kohara H, Morita Y, Eguchi T, Takano-Yamamoto T, Yoshida N
  • Organizer: Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Denver, USA
• [Presentation] IL-18 inhibits TNF-α-induced osteoclastogenesis in synergy with IL-12 in vivo (2009)
  • Author(s): Morita Y, Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Eguchi T, Takano-Yamamoto T, Yoshida N
  • Organizer: Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Denver, USA
• [Presentation] IFN-γ-mediated nitric oxide inhibits proliferation of M-CSF-dependent bone marrow macrophages (2009)
  • Author(s): Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, Takano-Yamamoto T, Yoshida N
  • Organizer: Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Denver, USA
• [Presentation] TNF-αによる破骨細胞形成に対してのT細胞のかかわりについての検討 (2009)
  • Author(s): 北浦英樹、藤村裕治、吉松昌子、小原悠、森田幸子、江口俊子、吉田教明、山本照子
  • Organizer: 第68回日本矯正歯科学会大会
  • Place of Presentation: 福岡
• [Presentation] L-18による矯正学的歯の移動と歯根吸収の及ぼす影響について (2009)
  • Author(s): 森田幸子、北浦英樹、吉松昌子、藤村裕治、小原悠、江口俊子、吉田教明
  • Organizer: 第68回日本矯正歯科学会大会
• [Presentation] IL-12の破骨細胞形成抑制作用におけるT細胞の関与ついて (2009)
  • Author(s): 吉松昌子、北浦英樹、藤村裕治、小原悠、森田幸子、江口俊子、吉田教明
  • Organizer: 第68回日本矯正歯科学会大会
  • Place of Presentation: 福岡
• [Presentation] IFN-γ誘導性のNOによるM-CSF依存性破骨細胞前駆細胞の増殖抑制効果 (2009)
  • Author(s): 小原悠、北浦英樹、吉松昌子、藤村裕治、森田幸子、江口俊子、吉田教明
  • Organizer: 第68回日本矯正歯科学会大会
  • Place of Presentation: 福岡
• [Remarks]
  • URL: http://ortho.dh.nagasaki-u.ac.jp/
• [Remarks]
  • URL: http://ortho.dh.nagasaki-u.ac.jp/