Basic research on bone regenerative medicine using dental pulp cells and periodontal ligament cells
| Project/Area Number |
21592615
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAWA Hiroo 松本歯科大学, 総合歯科医学研究所, 教授 (90147637)
NAKAMURA Hiroshi 松本歯科大学, 歯学部, 講師 (00278178)
NAKAMICHI Yuuko 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
UDAGAWA Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯髄細胞 / 歯根膜細胞 / カーボンナノチューブ / 石灰化 / BMP / Wntシグナル / マウス / ヒト / 再生医学 / 石灰化機構 / 硬組織再生 / annexin / Slc20a2 / 骨髄細胞 / 歯髄 / 歯根膜 / 骨形成 / 骨髄間葉系細胞 / 再生医療 / 細胞移植 / 骨誘導因子 |
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| Research Abstract |
Dental pulp cells are considered to be a promising tool for the regeneration of hard tissues, due to their multipotency. Mouse dental pulp cells exhibited strong alkaline phosphatase and extracellular matrix calcification activity even in the absence of exogenous rhBMP-2.The transplanted dental pulp cells into immunodeficiency mice exert bone regenerative activity in vivo. In addition, human dental pulp cells also exhibited strong alkaline phosphatase and extracellular matrix calcification activity.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Lineage-committed osteoclast precursors circulate in blood and settle down into bone.2012
Author(s)
Muto, A, Mizoguchi, T, Udagawa, N., Ito, S, Kawahara, I, Abiko, Y, Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y, Penninger, JM, Noguchi, T, Takahashi, N.
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Journal Title
J Bone MinerRes.Dec;
Volume: 26
Pages: 2978-2990
DOI
Related Report
Peer Reviewed
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